FATTY CHANGE Excessive entry of free fatty acids into the liver (starvation, corticosteroid therapy) Enhanced fatty acid synthesis. Decreased fatty acid oxidation. Increased esterification of fatty acid to triglycerides(alcohol) Decreased apoprotein synthesis(Ccla). Impaired lipoprotein secretion from the liver (alcohol)
• Excessive entry of free fatty acids into the liver (starvation, corticosteroid therapy). • Enhanced fatty acid synthesis. • Decreased fatty acid oxidation. • Increased esterification of fatty acid to triglycerides (alcohol). • Decreased apoprotein synthesis (CCl4). • Impaired lipoprotein secretion from the liver (alcohol). FATTY CHANGE
Morphology of fatty change Sudan ii oil red o. osmic acid Liver heart e Kidney
•Morphology of fatty change Sudan III, Oil red O, Osmic acid •Liver •Heart •Kidney
Hyaline changes(degeneration) Intracellular hyaline changes Hyaline degeneration of arterioles Hyaline degeneration of connective tissue
•Intracellular hyaline changes •Hyaline degeneration of arterioles •Hyaline degeneration of connective tissue Hyaline changes (degeneration)
Intracellular hyaline changes Absorption of protein causing hyaline droplets in proximal epithelial cells in the kidney. Russel bodies in plasma cells Viral inclusions in the cytoplasm or the nucleus Masses of altered intermediate filaments Mallory bodies)
• Absorption of protein causing hyaline droplets in proximal epithelial cells in the kidney. • Russel bodies in plasma cells. • Viral inclusions in the cytoplasm or the nucleus. • Masses of altered intermediate filaments (Mallory bodies). Intracellular hyaline changes