Something we learn from textbook White fat cell -Store energy Monolocular(单房的)Q Brown fat cell Dissipate energy Thigh mitochondrial UCPl(uncoupling protein 1) Multilocular In small mammals, not in large mammals after infancy
Something we learn from textbook • White fat cell – Store energy – Monolocular(单房的) • Brown fat cell – Dissipate energy [high mitochondrial UCP1(uncoupling protein 1)] – Multilocular – In small mammals, not in large mammals after infancy
Some new progress ·“ brown conversion” of white fat cold or cAMP White fat tissue ·UCP1+ UCP1 brown fat cell UCP1+ Derived from myf-5 lineage Brown fat in adult humans UCP1+ Particularly in supraclavicular and neck region
Some new progress • “brown conversion”of white fat • Brown fat in adult humans – UCP1+ – Particularly in supraclavicular and neck region cold or cAMP White fat tissue • UCP1﹣ brown fat cell • UCP1+ • Derived from myf-5 lineage • UCP1+
Questions Beige fat cell is a distinct cell type or derived from white fat cells The brown fat tissue in adult human is classical brown fat or beige fat
Questions • Beige fat cell is a distinct cell type or derived from white fat cells ？ • The brown fat tissue in adult human is classical brown fat or beige fat ?
么}NR Public access Manuscript p HEAD Cell. Author manuscript: available in PMC 2013 July 20 Published in final edited form as Ce.2012July20:1502):366-376.doi:10.1016/12012.05.016 U> Beige Adipocytes are a distinct Type of Thermogenic Fat cell in Mouse and human c0o Jun Wu, Pontus Bostrom, Lauren M. Sparks LiYe, Jang Hyun Choi, An-Hoa Giang Melin Khandekar', Pirjo Nuutila5, Gert Schaart, Kexin Huang 6, Hua Tu6, Wouter D. van Marken Lichtenbelt. Joris Hoeks 2 Sven Enerback Patrick Schrauwen 2 and Bruce M spiegelman WAT: white adipose tissue BAT: brown adipose tissue Lecturer: Cao lijie
第一PPT模板网 Lecturer: Cao Lijie WAT: white adipose tissue BAT: brown adipose tissue
Beige adipocyte in white fat eige fat cell readily detectable in Inguinal subcutaneous fat depot ; Multilocular UCP1 between Wat and BAT Adipose tissues a Bat BAT 口|n E Inguinal subcutaneous fat depot 口Epi pididymal WaT [Ucp-T CIdea Pac-a t) Brown fat cell-enriched protein
Beige adipocyte in white fat • Multilocular • UCP1 between WAT and BAT BAT Inguinal subcutaneous fat depot Epididymal WAT Brown fat cell-enriched protein Beige fat cell readily detectable in Inguinal subcutaneous fat depot
Beige adipocyte in white fat Immortalization(无限增殖) ○○○○○…○○○○○○…○ cell lines differentiate ○○O○○○○⑦6.6 White fat cell ll ige fat cel Beige fat cell is derived from a subset of precursor cells within white fat
Beige adipocyte in white fat … … Ing Immortalization(无限增殖) cell lines White fat cell beige fat cell Beige fat cell is derived from a subset of precursor cells within white fat. differentiate … …
characteristics of Beige cells A Basal state Stimulated state)(By cAMP 920 ■Bat NS 箫 c9-009x00≥00Y 口Bege o White 箫酱 50 Jcp-1 Cidea CoX7a1 Bat Beige White Brown fat- enriched protein
characteristics of Beige cells Brown fat-- enriched protein (By cAMP)
Brown fat in adult humans are beige fat cells Beige-selective genes p=00029 p=0032 p=0.002 品巴8 WAT "BAT WAT BAT WAT BAT CD137 TMEM26 TBX1 D Brown- selective gene p=0.024 p=0.7 p=0.083 15 ①10 coo0ooo "BAT WAT BAT JAT BAT EBF3 EVA1 FBXO31
Brown fat in adult humans are beige fat cells
highlights subQ WAT Beige adipogenic cells o White adipogenic cells Sympathetic stimulation Beige adipocyte Brown"fat in human adults is composed of beige adipocytes
highlights “Brown” fat in human adults is composed of beige adipocytes subQ WAT Beige adipogenic cells White adipogenic cells Beige adipocyte Sympathetic stimulation