STRESS-RELATED PATHWAY 1307110302ZQ
11307110302 ZQ
KEY WORDS ° Stress Ghrelin胃饥饿素 Growth hormone Amygdala杏仁核 Auditory fear conditioning Fear learning
• Stress • Ghrelin 胃饥饿素 • Growth hormone • Amygdala 杏仁核 • Auditory fear conditioning • Fear learning
Ghrelin- growth hormone axis Chronic stress Ghrelin个 Ghrelin receptors located in amygdala Growth hormone↑ Enhancement of fear learning
• Chronic stress • Ghrelin • Ghrelin receptors — located in amygdala • Growth hormone • Enhancement of fear learning Ghrelin- growth hormone axis
Sham Stressed Unstressed ADX surgery Group A Group B Group C Group D
Stressed Unstressed ADX Sham surgery Group A Group B Group C Group D
100 Statistical significance Indicating ghrelin is taking a role NS STR NS STR SHAM ADX ≤1 NS STR NS STR SHAM DX AD
Statistical significance • Indicating ghrelin is taking a role
Long-term pharmacological stimulation of ghrelin receptor activity in unstressed ats b 100 80 60 40 L 24h24h24h 20 Test VEH: 5d MK: 5d MK0677 VEH: saline(生理盐水)
Long-term pharmacological stimulation of ghrelin receptor activity in unstressed rats. MK-0677: a ghrelin receptor agonist VEH: saline (生理盐水)
Ghrelin receptor antagonism during chronic stress abolishes stress-related enhancement of fear memory. 100 60 N 840 20 0 VEH DLyS3 VEH DLyS3 NS STR
• Ghrelin receptor antagonism during chronic stress abolishes stress-related enhancement of fear memory
THANK YOU! Q&A Figures from [A ghrelin-growth hormone axis drives stress-induced vulnerability to enhanced fear]
THANK YOU! Q&A Figures from [A ghrelin–growth hormone axis drives stress-induced vulnerability to enhanced fear]
