Chapter Il. Inflammation 炎症 Zhigang Zhang Ph. D Department of Pathology, shanghai Medical College
Zhigang Zhang Ph.D Department of Pathology, Shanghai Medical College Chapter Ⅲ. Inflammation 炎 症
inflammation is a spine of pathology erysipelas burn
“ inflammation is a spine of pathology ” erysipelas burn
炎
炎
I Overview of inflammation Definition: Inflammation is the reaction of living tissues to all forms of injury a defensive response of living tissue with a complex reaction in vascularized connective tissue and cellular reaction intended to eliminate the initial cause as well as the necrotic cells and tissues
Ⅰ. Overview of inflammation Definition: Inflammation is the reaction of living tissues to all forms of injury. A defensive response of living tissue with a complex reaction in vascularized connective tissue and cellular reaction intended to eliminate the initial cause as well as the necrotic cells and tissues
inflammation Tw0 main components Vascular reaction Cellular reaction PRotective response Eliminate the initial cause Destroy harmful agents INtertwined with the process of repair Reconstitute damaged tissue
Two main components: Vascular reaction Cellular reaction Protective response: Eliminate the initial cause Destroy harmful agents Intertwined with the process of repair Reconstitute damaged tissue inflammation
Inflammation is a double blade sword Have Potential to cause harm Basically a protective reaction The basis of life threatening allergic .Desdroy dilute or isolate reaction to insect or drugs InJurious agents .Pericardial inflammation Clear inflammation resulting in dense encasing scar that impair heart .Make wound tissue function healing Chronic inflammation often cause fibrosis of diseased organs
Inflammation is a double blade sword Basically a protective reaction •Desdroy, dilute or isolate injurious agents •Clear inflammation •Make wound tissue healing Have Potential to cause harm •The basis of lifethreatening allergic reaction to insect or drugs •Pericardial inflammation resulting in dense encasing scar that impair heart function •Chronic inflammation often cause fibrosis of diseased organs
bacteria and toxins Chemical Acids alkalis Microbial cooling Inflammatory causes allergIc radiation burns Physical others Trauma Tissue necrosis Foreign bodies
Inflammatory causes bacteria and toxins Trauma Microbial Tissue necrosis Foreign bodies radiation Physical Acids alkalis cooling Chemical allergic burns others
Infection感染 Caused by microbial agents t( Infectious disease,传染病) proliferate and spread people to people release toxin and enzymes A induce immune reaction AIDS。 Tuberculosis
Infection 感染 Caused by microbial agents (Infectious disease,传染病） proliferate and spread people to people release toxin and enzymes induce immune reaction AIDS, Tuberculosis
I. Basic Pathologic Changes of Inflammation Alteration(3E): degeneration and necrosis(Necrostic type) (massive necrosis of liver in fulminant hepatitis Exudation(渗出): vascular changes, (inflammatory hyperemia) extravasation of leukocyte and fluid (common cold, watery exudate on mucous membrane of nose) proliferation(#4E): epithelium, connective tissue, and blood vessels (granuloma, tonsillitis
Alteration(变质): degeneration and necrosis (Necrostic type) Exudation(渗出): vascular changes, (inflammatory hyperemia) extravasation of leukocyte and fluid (common cold, watery exudate on mucous membrane of nose) proliferation(增生): epithelium, connective tissue, and blood vessels (glanuloma, tonsillitis ) II. Basic Pathologic Changes of Inflammation (massive necrosis of liver in fulminant hepatitis )
Normal structure of liver A念 3示t Massive necrosis of liver tissue
Normal structure of liver Massive necrosis of liver tissue