免疫学 Immunology 湖儿大学生命种学学院 生物技术教研室 余晓岚
余晓岚 免疫学 Immunology 湖北大学生命科学学院 生物技术教研室
推动现代生命科学前进的三架马车 分子生物学( Molecular Biology) 免疫学( Immunology) 细胞生物学( Cell Biology)
推动现代生命科学前进的三架马车 • 分子生物学（Molecular Biology） • 免疫学（Immunology） • 细胞生物学（Cell Biology）
免疫学的基本内容 免疫学的简介 免疫应答的类型及作用 免疫细胞 四、免疫组织与免疫器官 五、免疫病理与免疫性疾病
• 一、免疫学的简介 • 二、免疫应答的类型及作用 • 三、免疫细胞 • 四、免疫组织与免疫器官 • 五、免疫病理与免疫性疾病 第一章 免疫学的基本内容
第一节概述 免疫( Immunity)指免除疫病(传染病) 及抵抗多种疾病的发生。 Distinguishes self from"non-self Danger Hypothesis °“ Protection” from infection, tumors,etc o A response that may result in host tissue damage
第一节 概述 免疫（Immunity）: 指免除疫病(传染病) 及抵抗多种疾病的发生。 • Distinguishes “self” from “non-self” • Danger Hypothesis • “Protection” from infection, tumors, etc. • A response that may result in host tissue damage
Host Defense Inborn independen of previous Innate experlence ter natural Active Exposure to a foreig! agent Defense Natural Passive placental transfer Mechanisms acquired immune cells in colostrum Acquired Active Specific immunization Artificiall Passive H administration of acquired preformed antibodie Adoptive Bone marrow transplan
Host Defense Defense Mechanisms Innate Inborn independent of previous experience Acquired Naturally acquired Active Adoptive Passive Active Adoptive Passive after natural exposure to a foreign agent placental transfer immune cells in colostrum Artificially acquired Specific immunization administration of preformed antibodies Bone marrow transplant immune cells in colostrum
宿主体内的免疫系统谀别和清除 统三大物的生和病现 功能生理性反应(有利)病理性反应(有害) 免疫防御清除病原微生畅 及其他抗原 超敏反应(过度) 免疫缺陷病(不足) 免疫自稳请除损伤或衰老 自身免疫病 的细胞,免疲网 絡调节免疫应答 免疫监视清除突吏或哈变 肿癖发生 的恶性细胞 持续病毒感染
宿主体内的免疫系统识别和清除
免疫系统是由免疫组织和器官、免疫细胞及 免疫活性分子等组成。 免疫细胞对病原体或肿瘤细胞的适当应答, 使之清除。 免疫应答过高或过低,均为异常
• 免疫系统是由免疫组织和器官、免疫细胞及 免疫活性分子等组成。 • 免疫细胞对病原体或肿瘤细胞的适当应答， 使之清除。 • 免疫应答过高或过低，均为异常
第二节免疫应答的类型及作用 固有免疫应答( innate immune response)皮肤黏膜、局部分泌物质、吞 噬细胞、NK细胞和补体 适应性免疫应答( adaptive immune response)T、B细胞
第二节 免疫应答的类型及作用 • 固有免疫应答（inanate immune response）皮肤黏膜、局部分泌物质、吞 噬细胞、NK细胞和补体 • 适应性免疫应答（adaptive immune response） T、B细胞
Two types of immunity- Innate immunity(not antigen-specific) Anatomical barriers Mechanical Biochemical Non-specific(eg. Low pH in stomach) o Receptor-driven(eg. PAMP-recognition) Adaptive immunity(antigen-specific) Receptor-drⅳven Pre-existing clones programmed to make a speciTIc immune response (humoral/cellular)
Two types of immunity • Innate immunity (not antigen-specific) – Anatomical barriers – Mechanical – Biochemical • Non-specific (eg. Low pH in stomach) • Receptor-driven (eg. PAMP-recognition) • Adaptive immunity (antigen-specific) – Receptor-driven – Pre-existing clones programmed to make a specific immune response (humoral/cellular)
The products of the immune response may be used To diagnose disease O To monitor disease progress As reagents in assays to detect and quantify other substances
The products of the immune response may be used • To diagnose disease • To monitor disease progress • As reagents in assays to detect and quantify other substances