CHCMU 道天这科天学粥属儿童长交 VitD的营养 重庆医科大学儿科学院 儿童保健教研室 程茜 教授
VitD的营养 重庆医科大学儿科学院 儿童保健教研室 程茜 教授
CHCMU 本课目的要求 ·了解维生素D的生理功能 ·熟悉维生素D的来源、代谢 •掌握维生素D缺乏的发病机理及病理变化 ·掌握维生素D缺乏性佝偻病的诊断及鉴别诊断 熟悉维生素D缺乏的预防 •了解维生素D手足搐搦症和过量 www.chcmu.com
本课目的要求 •了解维生素D的生理功能 •熟悉维生素D的来源、代谢 •掌握维生素D缺乏的发病机理及病理变化 •掌握维生素D缺乏性佝偻病的诊断及鉴别诊断 •熟悉维生素D缺乏的预防 •了解维生素D手足搐搦症和过量
CHCMU 以度科天 维生素D的生理功能 THE SUN AND VITAMIN D POSSIBLE EFFECTS OF VITAMIN D DEFICIENCY SUN Bra Schizophrenia convert a derivative of cholesterol ·Depression already present in 参与钙磷代谢 the skin-into Lungs Vitamin D3,which ·Asthma then travels to ·Wheezing the liver. D3 SKIN D3 Circulatory ·High blood pressure ● 调节免疫功能 ②The liver converts D3 Coronary heart disease D3 ·Stroke D3D3 Muscles/bones 抗癌作用 Muscle weakness,aches is what doctors ·Rickets measure in the ·Osteoporosis blood. Osteomalacia (soft bones) 与糖尿病、肥胖等有关 ③The kidneys convert this form Immune System to the final active Type 1 diabetes hormone that may ·Multiple sclerosis have many effects throughout the Rheumatoid arthritis body,including enabling calcium Weakened response to absorption in the intestines. fight turberculosis. influenza and othe infectious diseases OTHER SOURCES OF VITAMIN D Vitamin D3 can be found in Cancer Possibly associated with fortified milk.sc me foods and sted this way.D3 a vanety of cancers. makes i including colon,breast, prostate and ovarian the liver and skinproduced vminm scientists say current recommendations for daily Vitamin D intake are inadequate
维生素D的生理功能 • 参与钙磷代谢 • 调节免疫功能 • 抗癌作用 • 与糖尿病、肥胖等有关
CHCMU SOURCES of VITAMIN D vitD BIRTH DIET SUN www.chcmu.com
BIRTH DIET SUN vitD SOURCES of VITAMIN D
CHCMU 食畅VitD的含量 母乳40U/ 牛奶5-40U/L 蛋70U/100g 黄油30-60U/100g 强化食物VitD含量 AD强化奶6001U/L(390IU/660ml) 婴儿配方奶4001U/100g（758ml) 奶米粉400U/100g(160U/40g.d) www.c
食物VitD的含量 母乳40IU/L 牛奶5-40IU/L 蛋70IU/100g 黄油30-60IU/100g 强化食物VitD含量 AD强化奶600IU/L（390IU/660ml） 婴儿配方奶400IU/100g（758ml） 奶米粉400IU/100g（160IU/40g.d）
CHCMU SOURCES of VITAMIN D vitD 影响日照效果的因素 •暴露的皮肤面积：遮盖物、 防晒产品等 ·日照的时间：季节、生活方 式等 紫外线的波长：季节、空气 SUN 污染等 www.chcmu.com
SUN vitD SOURCES of VITAMIN D 影响日照效果的因素 •暴露的皮肤面积：遮盖物、 防晒产品等 •日照的时间：季节、生活方 式等 •紫外线的波长：季节、空气 污染等
CHCMU Vitamin D Metabolism Mineral Homeostasis Major source-sunlight Skin Cholecalciferol 7-Dehydrocholesterol (vitamin D3) Minor source-dietary intake Vitamin Da(fish,meat) Vitamin D2(vitamin supplements) Live 25-dihydroxyvitamin Da 25-OHD3可以反映体内维生素D的 营养状况 1.25-dihydroxyvitamin Da Kidney Calcium absorption(small intestine) tUrinary calcium re-absorption(kidney) 个Bone mineralisation Maintains calcium balance in the body via the action of parathyroid hormone www.chcmu.com
Vitamin D Metabolism & Mineral Homeostasis 25-OHD3可以反映体内维生素D的 营养状况
®6调节 CHCMU VitD3 肝 自身反馈 25-(0H)D3 低血磷 (+) 高血磷 (+) 甲状旁腺素 降钙素 自身反馈 +)1 ↑(+) 低血钙 高血钙 1,25-(0H)2D3 www.chcmu.com
VitD3 肝 肾 1,25-(OH)2D3 低血磷 高血磷 甲状旁腺素 降钙素 低血钙 (+) (+) (+) (+) (-) (-) VitD3 肝 25-(OH)D3 高血钙 (+) (+) (-) 自 身 反 馈 自 身 反 馈 VitD的调节
CHCMU 天 Risk Factors for Vit D Deficiency Lack of sunshine exposure Lack of vitamin D supplements Poor vitamin D stores at birth Maternal vitamin D deficiency Others www.chcmu.com
Risk Factors for Vit D Deficiency ▪ Lack of sunshine exposure ▪ Lack of vitamin D supplements ▪ Poor vitamin D stores at birth ▪ Maternal vitamin D deficiency ▪ Others
CHCMU VitD缺乏性佝偻病 rickets of vitamin D deficiency www.chcmu.com
VitD缺乏性佝偻病 rickets of vitamin D deficiency