Medical Immunology Department of Immunology Yiwei Chu 储以微 yichu@shmu.edu.cn 2010-7-7
Medical Immunology Department of Immunology Yiwei Chu 储以微 ywchu@shmu.edu.cn 2010-7-7
Define of immunology IMMUNITY protection from disease(infectious disease) IMMUNE SYSTEM organ, cel, molecule and gene IMMUNE RESPNSE response to the foreign substances
IMMUNITY ---protection from disease (infectious disease) IMMUNE SYSTEM --- organ, cell, molecule and gene IMMUNE RESPNSE --- response to the foreign substances Define of Immunology
Define of immunology IMMUNE FUNCTIONS immune defence(infectious disease) immune surveillance immune homeostasis
IMMUNE FUNCTIONS ---immune defence (infectious disease) --- immune surveillance --- immune homeostasis Define of Immunology
Define of immunology IMMUNITY protection from disease(infectious disease) IMMUNE SYSTEM organ, cel, molecule and gene IMMUNE RESPNSE response to the foreign substances
IMMUNITY ---protection from disease (infectious disease) IMMUNE SYSTEM --- organ, cell, molecule and gene IMMUNE RESPNSE --- response to the foreign substances Define of Immunology
Innate and Adaptive Immunity Innate Adaptive Characteristics Specificity For structures shared by For antigens of microbes and groups of related microbes for nonmicrobial antigens Diversity Limited: germline-encoded Very large: receptors are produced y somatic recombination of gene segments Memory None Yes Nonreactivity to selfYes Yes Components Physical and Skin, mucosal epithelia Lymphocytes in epithelia chemical barriers antimicrobial chemicals antibodies secreted at epithelial surfaces Blood proteins Complement Antibodies Cells Phagocytes(macrophages. Lymphocytes neutrophils), natural killer cells
Innate and Adaptive Immunity
Adaptive Immune Responses Feature I Functional significance Specificity E sures that distinct antigens elicit specific responses Diversity Enables immune system to respond to a large variety of antigens Memory Leads to enhanced responses to repeated exposures to the same antigens Specialization Generates responses that are optimal for defense against different types of microbes Self-limitation Allows immune system to respond to newly encountered antigens Nonreactivity Prevents injury to the host during to self responses to foreign antigens
Adaptive Immune Responses
Adaptive Immune Responses Cellular Components Lymphocytes B, Th CTL nKt Antigen-presenting cells(APCs) DC Mo, B Effector cells Activated T cells, mononuclear phagocytes
Cellular Components Adaptive Immune Responses • Lymphocytes - B, Th, CTL, NKT • Antigen-presenting cells(APCs) - DC, Mj, B • Effector cells - Activated T cells, mononuclear phagocytes
Basic Immunology Recognition Activation Effection Ag(antigen) double recognition humural immunity APC double signaling cellular immunity (antigen presenting cell)
Basic Immunology Recognition Activation Effection Ag (antigen) double recognition humural immunity APC double signaling cellular immunity (antigen presenting cell)
Chapter 1 efinition ofantigen Antigen(Ag) Substances that combine specifically with a B or T cell's antigen-binding receptors can then induce an immune response are called antigens
Antigen (Ag) Chapter 1 Definition of antigen Substances that combine specifically with a B or T cell’s antigen-binding receptors can then induce an immune response are called antigens
Chapter 2 Characteristics ofantigen The antigen molecule generally pose two natures, that is (1) immunogenicity (2) antigenicity
Chapter 2 Characteristics of antigen （1）immunogenicity （2）antigenicity The antigen molecule generally pose two natures, that is