AUTOIMMUNITY AND ATONMMUNE DTSEASE Bo Gao, Ph. D. email: gb1112@163.com Tel:54237379 DEPARTMENT OF IMMUNOLOGY INSTITUTE FOR IMMUNOBIOLOGY 2010-07-02 1
1 Bo Gao, Ph.D. DEPARTMENT OF IMMUNOLOGY INSTITUTE FOR IMMUNOBIOLOGY 2010-07-02 Email: gb1112@163.com Tel: 54237379
Contents: g Introduction c Organ-Specific Autoimmune Diseases e Systemic Autoimmune Diseases Mechanisms of induction g Treatment
2 Contents: Introduction Organ-Specific Autoimmune Diseases Systemic Autoimmune Diseases Mechanisms of Induction Treatment
ntroduction
3 Introduction
Autoimmunity origins y Horror autotoxicus Literally the horror of self- toxicity a term coined by the German immunologist paul Ehrlich(1854-1915) to describe the body's innate aversion to immunological self-destruction Paul Ehrlich. Nobel Prize in 1908 for demonstrating production of anti body
4 Autoimmunity Origins ➢Horror autotoxicus: Literally, the horror of selftoxicity. A term coined by the German immunologist Paul Ehrlich (1854-1915) to describe the body's innate aversion to immunological self-destruction. Paul Ehrlich , Nobel Prize in 1908 for demonstrating production of antibody
Clone selection hypothesis >Self-reactive lymphocyte were deleted during development Frank Burnet 1900--1990 E Nobel Prize 1960
5 Frank Burnet 1900--1990 Nobel Prize 1960 Clone selection hypothesis ➢Self-reactive lymphocyte were deleted during development
Definition of autoimmune disease Disease caused by failure of self-tolerance and subsequent Immune responses against self antigens are called autoimmune diseases
6 Definition of autoimmune disease ➢Disease caused by failure of self-tolerance and subsequent immune responses against self antigens are called autoimmune diseases
>5 to 7 adult affected >Two third women More than 40 human diseases autoimmune in origin
7 ➢5 % to 7% adult affected. ➢Two third women. ➢ More than 40 human diseases autoimmune in origin
Two types of autoimmune disease organ-specific non-organ-specific brain multiple sclerosis(?) thyroid Hashimoto·s thyroiditis primary myxoedema thyrotoxicosis muscle dermatomyositis stomach pernicious anaemia kidney SLE adrenal Addison's disease skin scleroderma pancreas SLE insulin-dependent diabetes mellitus Joints rheumatoid arthritis
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Organ-Specific Autoimmune Diseases >Insulin-dependent diabetes mellitus > Multiple sclerosis >Myasthenia gravis >Graves's disease >Hashimoto disease > Goodpasture's syndrome
9 ➢Insulin-dependent diabetes mellitus ➢Multiple sclerosis ➢Graves’s disease ➢Myasthenia gravis ➢Hashimoto’ disease ➢Goodpasture’s syndrome …… Organ-Specific Autoimmune Diseases
Systemic autoimmune Diseases
10 Systemic Autoimmune Diseases