e DEPARTMENT OF IMMUNOBIOLOGY Antigens(Ag) Xiaowu hong xiaowuhong@fudna.edu.cn 021-54237093 Department of Immunology Shanghai medical college of Fudan University
DEPARTMENT OF IMMUNOBIOLOGY Antigens (Ag) Xiaowu Hong xiaowuhong@fudna.edu.cn 021-54237093 Department of Immunology Shanghai Medical College of Fudan University
antigen I Definition and characteristics of antigen I Properties ofAg: Foreignness and specificity Il Factors that influence immunogenicity IV Classification of antigen V Nonspecific stimuli for immune response
I Definition and characteristics of antigen II Properties of Ag: Foreignness and specificity III Factors that influence immunogenicity IV Classification of antigen V Nonspecific stimuli for immune response antigen
Chapter 1 efinition ofantigen Antigen(Ag) Substances that combine specifically with a B or T cell's antigen-binding receptors can then induce an immune response are called antigens
Antigen (Ag) Chapter 1 Definition of antigen Substances that combine specifically with a B or T cell’s antigen-binding receptors can then induce an immune response are called antigens
Antigen(Ag Antigen binding triggers release of antibodies Antigen binding causes cytotoxic T cells Activated B ce Memory Activated Memory T cell cytotoxic T cell Antibodies B cel
Antigen (Ag) Antigen binding causes cytotoxic T cells Memory T cell Activated cytotoxic T cell Antigen binding triggers release of antibodies Memory B cell Activated B cell Antibodies
Chapter 2 Characteristics ofantigen The antigen molecule generally pose two natures, that is (1) immunogenicity (2) antigenicity
Chapter 2 Characteristics of antigen （1）immunogenicity （2）antigenicity The antigen molecule generally pose two natures, that is
(1)Immunogenicity Immunogenicity is the ability to induce a humoral and or cell mediated immune response, including Activated b cell induce production 人 of antibody and effector Activated Ctl lymphocytes antibody
(1) Immunogenicity Immunogenicity is the ability to induce a humoral and / or cell mediated immune response, including induce production of antibody and effector lymphocytes. Activated B cell antibody Activated CTL
(2) antigenicity Antigenicity is the ability to combine specifically with the final products of the above responses(i.e anti body and or cell-surface receptors)
(2) antigenicity Antigenicity is the ability to combine specifically with the final products of the above responses (i.e., antibody and /or cell-surface receptors)
antigenicity T T Ag i mmuogen icity
antigenicity immuogenicity T T T Ag
Specificity Specificity of antigen The characteristic that antigen only binds the antibody and sensitized lymphocyte specifically, is called specificity of antigen Specificity
1 Specificity Specificity of antigen The characteristic that antigen only binds the antibody and sensitized lymphocyte specifically, is called specificity of antigen（ Specificity ）
(1)Antigenic determinants or epitopes Antigenic determinants or epitopes are the immunologically active regions of an immunogen that bind to antigen-specific membrane receptors on lymphocytes (TCR/BCR)or to secreted antibodies
Antigenic determinants or epitopes are the immunologically active regions of an immunogen that bind to antigen-specific membrane receptors on lymphocytes (TCR/BCR) or to secreted antibodies. (1) Antigenic determinants or epitopes