明正 道谊 Antigen Presenting Cell and Antigen Presentation Haifeng Gao hfgao@fudan.edu.cn DEPARTMENT OF IMMUNOLOGY
Antigen Presenting Cell and Antigen Presentation Haifeng Gao hfgao@fudan.edu.cn DEPARTMENT OF IMMUNOLOGY
4 Antigen Presenting Cells ◆ Antigen Processing Antigen Presentation
Antigen Presenting Cells Antigen Processing Antigen Presentation
First line of defense Innate Immunit Native N on-specifIc No memory to antigens A cquired Adaptive Immunity Specific Memory to antigens Recognition by receptor
First line of defense Native Non-specific No memory to antigens Acquired Specific Memory to antigens Recognition by receptor Innate Immunity Adaptive Immunity
Antigen Presenting Cell, APC Antigen fragment SMHC TCR\ Pathogens APC T Cell
Antigen Presenting Cell, APC APC Antigen fragment MHC TCR Pathogens T Cell
CONCEPT APCs are immunocytes that can uptake, process and present antigens to other lymphocytes
APCs are immunocytes that can uptake, process and present antigens to other lymphocytes. CONCEPT
CLASIFICATION Dendritic cell Macrophage B lymphocyte a。分 备B8 Figure 1-22 part 1 of 3 Immunobiology, 6/e. (e Garland Science 2005) Professional APC: constitutively express MHc II molecules MHCI
Professional APC: constitutively express MHC II molecules CLASIFICATION MHC I