明正 道谊 Antigen Presenting Cell and Antigen Presentation Haifeng Gao hfgao@fudan.edu.cn DEPARTMENT OF IMMUNOLOGY
Antigen Presenting Cell and Antigen Presentation Haifeng Gao hfgao@fudan.edu.cn DEPARTMENT OF IMMUNOLOGY
4 Antigen Presenting Cells ◆ Antigen Processing Antigen Presentation
Antigen Presenting Cells Antigen Processing Antigen Presentation
First line of defense Innate Immunit Native N on-specifIc No memory to antigens A cquired Adaptive Immunity Specific Memory to antigens Recognition by receptor
First line of defense Native Non-specific No memory to antigens Acquired Specific Memory to antigens Recognition by receptor Innate Immunity Adaptive Immunity
Antigen Presenting Cell, APC Antigen fragment SMHC TCR\ Pathogens APC T Cell
Antigen Presenting Cell, APC APC Antigen fragment MHC TCR Pathogens T Cell
CONCEPT APCs are immunocytes that can uptake, process and present antigens to other lymphocytes
APCs are immunocytes that can uptake, process and present antigens to other lymphocytes. CONCEPT
Toy- body T-cell T-cell epitope CD4 T APC
Can all APCs stimulate T cells to proliferate?
Can all APCs stimulate T cells to proliferate?
CLASIFICATION Dendritic cell Macrophage B lymphocyte a。分 备B8 Figure 1-22 part 1 of 3 Immunobiology, 6/e. (e Garland Science 2005) Professional APC: constitutively express MHc II molecules MHCI
Professional APC: constitutively express MHC II molecules CLASIFICATION MHC I
Professional APCs Dendritic Cells (DCs) Macrophages(Md) B Lymphocytes
Dendritic Cells (DCs) Macrophages (M) B Lymphocytes Professional APCs
Non-professional APCs E ndothelial cells Epithelial Cells Fibroblast cells Non-professional APC: express MHCI molecules
Endothelial Cells Epithelial Cells Fibroblast Cells …… Non-professional APCs Non-professional APC: express MHC I molecules