Development of the metathesis method in organic synthesis The Nobel Prize in Chemistry 2005 PDF文件使用"pdfFactory Pro”试用版本创建w,fineprint.com,cn
Development of the metathesis method in organic synthesis ——The Nobel Prize in Chemistry 2005 PDF 文件使用 "pdfFactory Pro" 试用版本创建 \www.fineprint.com.cn Ì
Nobel Prizes for synthetic methodologies Year Laureates Contributions 1912 Victor Grignard for the discovery of the so-called Paul Sabatier Grignard reagent 1950 Otto Paul Hermann Diels for their discovery and development of Kurt Alder the diene synthesis 1979 Herbert C.Brown Phosphorus ylide Georg Wittig 2001 William S.Knowles Chirally catalysed hydrogenation Ryoji Noyori K.Barry Sharpless Chirally catalysed oxidation 2005 Yves Chauvin Development of the metathesis method Robert H.Grubbs Richard R.Schrock PDF文件使用"pdfFactory Pro'”试用版本创建wm,fineprint.com,cn
Nobel Prizes for synthetic methodologies Yves Chauvin Development of the metathesis method Robert H. Grubbs Richard R. Schrock 2005 Chirally catalysed hydrogenation Chirally catalysed oxidation William S. Knowles Ryoji Noyori K. Barry Sharpless 2001 Herbert C. Brown Phosphorus ylide Georg Wittig 1979 for their discovery and development of the diene synthesis Otto Paul Hermann Diels Kurt Alder 1950 for the discovery of the so-called Grignard reagent Victor Grignard Paul Sabatier 1912 Year Laureates Contributions PDF 文件使用 "pdfFactory Pro" 试用版本创建 Ìwww.fineprint.com.cn
Nobel Prizes for synthetic methodologies 1912 R'CH,OH Victor6 gnard■ Y山■ RCHROH ①1/2 of the prize X=Cl,Br,I R'X France Nancy University Nancy,France H.CO Mg Apthor RCHO RR COH b.1871 d.1935 RCOR R,CHOH HC0z士 RCN R'MOX RCOR (BOLed Ho or ackdic H Paul Sabatier D 1/2 of the prize RCOEt 8 R.COH RH France Toulouse University Toulouse,France b.1854 R'RCOH RCH CH OH d.1941 RCOH Typlcal wo★up for th●●aton: 1.Dute nqucous ndld or 2.Aqucous ammonlum chlorlde PDF文件使用"pdfFactory Pro”试用版本创建mw,fineprint..com,cn
1912 Nobel Prizes for synthetic methodologies b. 1871 d. 1935 Nancy University Nancy, France France 1/2 of the prize Victor Grignard b. 1854 d. 1941 Toulouse University Toulouse, France France 1/2 of the prize Paul Sabatier PDF 文件使用 "pdfFactory Pro" 试用版本创建 ÿwww.fineprint.com.cn
Nobel Prizes for synthetic methodologies 1950 Otto Paul Hermann Dlels ①l/2 of the prize Federal Republic of 本收 Germany Kiel University Kiel,Federal Republic of Germany d b.1876 d.1954 . Kurt Alder ①1/2 of the prize Federal Republic of "y" Germany Cologne University Cologne,Federal Republic 一O* of Germany b.1902 d.1958 o而出p PDF文件使用"pdfFactory Pro”试用版本创建ww.fineprint.com.cn
1950 Nobel Prizes for synthetic methodologies b. 1876 d. 1954 Kiel University Kiel, Federal Republic of Germany Federal Republic of Germany 1/2 of the prize Otto Paul Hermann Diels b. 1902 d. 1958 Cologne University Cologne, Federal Republic of Germany Federal Republic of Germany 1/2 of the prize Kurt Alder PDF 文件使用 "pdfFactory Pro" 试用版本创建 ÿwww.fineprint.com.cn
o aldol base condesation X.Y COOH,OH,NH2,COCI Robinson Annelation Reaction R R R PDF文件使用"pdfFactory Pro”试用版本创建ww,fineprint.com,cn
X Y X,Y = COOH, OH, NH2 , COCl …… O + O O O OH O base aldol condesation Robinson Annelation Reaction ( )n R3 R1 R4 R2 R1 R2 R3 R4 + R1 R3 R2 R4 PDF 文件使用 "pdfFactory Pro" 试用版本创建 www.fineprint.com.cn
Nobel Prizes for synthetic methodologies I979 Herbert C.Brown ①1/2 of the prize USA The Wittig reaction Purdue University West Lafayette,IN,USA R R Ph b.1912 C=0+ :C-P-Ph (in London,United Kingdom) R R Ph d.2004 ketone or aldehyde phosphorus ylide Georg Wittig R R 1/2 of the prize Ph,P=O Federal Republic of Germany R University of Heidelberg alkene Heidelberg,Federal Republic of Germany b.1897 d.1987 PDF文件使用"pdfFactory Pro”试用版本创建ww.fineprint.com.cn
1979 Nobel Prizes for synthetic methodologies b. 1912 (in London, United Kingdom) d. 2004 Purdue University West Lafayette, IN, USA USA 1/2 of the prize Herbert C. Brown b. 1897 d. 1987 University of Heidelberg Heidelberg, Federal Republic of Germany Federal Republic of Germany 1/2 of the prize Georg Wittig PDF 文件使用 "pdfFactory Pro" 试用版本创建 ÿwww.fineprint.com.cn
witting reaction CH3MgBr OH acid H20 PDF文件使用"pdfFactory Pro”试用版本创建ww,fineprint.com,cn
O witting reaction CH3MgBr OH acid -H2O PDF 文件使用 "pdfFactory Pro" 试用版本创建 www.fineprint.com.cn
Nobel Prizes for synthetic methodologies Z0U月工 Willam S.Knowies 1/4 of the prize 0-(-)-DET USA HOCOEt St.Louis,MO,USA (25,30 b.1917 d 0(-HDET Ryoji Noyori 1/4 of the prize Japan A 0 Nagoya University Nagoya,Japan HOCO2Et (+)-DET b.1938 2R,3 K.Barry Sharpless ①1/2 of the prize 人人人 -(+H-DET,TKO-P3 人 USA Geraniol c The Scripps Research Institute La Jolla,CA,USA b.1941 PDF文件使用"pdfFactory Pro”试用版本创建ww.fineprint.com.cn
2001 Nobel Prizes for synthetic methodologies b. 1917 St. Louis, MO, USA USA 1/4 of the prize William S. Knowles b. 1938 Nagoya University Nagoya, Japan Japan 1/4 of the prize Ryoji Noyori b. 1941 The Scripps Research Institute La Jolla, CA, USA USA 1/2 of the prize K. Barry Sharpless PDF 文件使用 "pdfFactory Pro" 试用版本创建 ÿwww.fineprint.com.cn
3 NObePlvcoenethod in organic synthesis" photo U.Montan hoto L.B Hether Yves Chauvin Robert H.Grubbs Richard R.Schrock 1/3 of the prize 1/3 of the prize 1/3 of the prize France USA USA Institut Francais du California Institute of Massachusetts Institu Petrole Technology (Caltech) te of Technology(MI Rueil-Malmaison, T)Cambridge.MA.U Pasadena,CA.USA France SA b.1930 b.1942 b.1945 PDF文件使用"pdfFactory Pro”试用版本创建ww,fineprint.com,cn
"for the development of the metathesis method in organic synthesis" The Nobel Prize in Chemistry 2005 Yves C hauvin 1/3 of the prize France Institut Français du P étrole R ueil-M alm aison, France b. 1930 R obertH . G rubbs 1/3 of the prize U S A C alifornia Institute of Technolo gy (C altech) P asadena, C A , U S A b. 1942 R ichard R . Schrock 1/3 of the prize U S A M assachusetts Institu te of Technolo gy (M I T) C am brid ge, M A , U SA b. 1945 PDF 文件使用 "pdfFactory Pro" 试用版本创建 Ìwww.fineprint.com.cn
Nobel Prize in Chemistry 2005 Introauction ▣What is metathesis? meta means change thesis means position catalyst Scheme 1 In short AB+CD→AC+BD PDF文件使用"pdfFactory Pro”试用版本创建ww.fineprint.com.cn
Introduction o What is metathesis? meta means change thesis means position Scheme 1 In short AB + CD → AC + BD Nobel Prize in Chemistry 2005 PDF 文件使用 "pdfFactory Pro" 试用版本创建 ÿwww.fineprint.com.cn
