韩珉教授简介 1982年北京大学 CUSBEA毕业后入选留美项目,1983年赴美 国加州大学洛山矶分校攻读博士学位。1988年获博士学位后在 加州理工学院从事博士后研究。1991年到卡罗拉多大学执教, 先后任助理教授、副教授、教授。97年被遴选为著名的休斯医 学研究所研究员。发现Ras途径在发育中的作用,所领导的研 究组在细胞信号转导和发育方面有诸多重要贡献,在Cell, Nature, Science等刊物上发表了多篇论文并获专利2项

once oncu n a paiuicuia positon on DNA, a nucleosome remained fixed in place because of the tight association 30-nm 98A5 sequence-specific DNA-binding proteins nucleosome

CELLULAR ADAPTATION Excessive physiologic stresses. Some pathologic stimuli. A new, but altered state preserving the viability of the cell

Virus a noncellular genetic element that enlists a cell for its own replication, it has an extracellular state. A virus particle containing nucleic acid surrounded by protein and other macromolecular components is called virion

Autopsy Biopsy Cytology Experimental studies In vitro: Tissue culture Organ culture Cell culture In vivo: Experimental animals Nude mice

Definition gestational trophoblastic disease(GTD)is a group of disease originated from placental villose trophoblastic cells, including hydatidiform mole, invasive mole, choriocarci- noma and a kind of less common trophoblastic cell tumor in placenta

Notes LECTURE Biochemistry 9.17.04 ATP is both a unit of energy currency in a cell and a building block of RNA. Why? It is believed that early in evolution there were very few molecules around. Many key pathways are ancient, and trace their origin to the early stages of evolution of life on Earth. Incidentally, such pathways are usually highly conserved in modern organisms. This is probably because once

Many intracellular proteins are required to interact or bind to other macromolecules within a bind DNA. Such proteins often have conserved structural features, called motifs, whis at can cell in order to function properly. One class of such proteins is comprised of proteins tha interact with DNA. One such motif consists of two closely aligned a-helices(shown as cylinders below)that each have leucine-rich regions. This motif is referred to as a leucine

11. 4. The nucleolus The most prominent substructure within the nucleus during interphase is the nucleolus. 100 years ago, one found a big spherical structure, called nucleolus within the nucleus, but up until 1960s, it was not identified that the nucleolus is a ribosome production factory designed to fulfill the need for large scale transcription and processing

Part l: Maintenance of the genome Dedicated to the structure of NA and the processes that propagate, maintain and alter it from one cell generation to the next