第六章线粒体的结构及生物功能 entricle Lysosome Nucleus Chromati 线粒体 Vacuole Nuclear menbrane Ribosomes Cytoplasm Golgi complex Smooth Microfilaments Microtubule reticulum
第六章 线粒体的结构及生物功能 线粒体
通过本章的学习,同学们应该掌握下述内容: 1.线粒体是真核生物细胞内的动力工厂 2.线粒体的特殊结构决定了它们能够给细胞提供生物能量 3线粒体是一种‘半自主性’的细胞器 4.线粒体与生命活动的关系 1)没有生物能量就没有生命 2)线粒体直接参与了细胞凋亡的信号途径 5线粒体异常与疾病
通过本章的学习,同学们应该掌握下述内容: 1. 线粒体是真核生物细胞内的动力工厂 2. 线粒体的特殊结构决定了它们能够给细胞提供生物能量 3. 线粒体是一种‘半自主性’的细胞器 4. 线粒体与生命活动的关系 1)没有生物能量就没有生命 2)线粒体直接参与了细胞凋亡的信号途径 5. 线粒体异常与疾病
线粒体的结构与功能:线粒体是含有双层膜结构的膜式细胞器 ATP synthase particles Intermembrane space Matrix Ribosome Cristae Granules Inner membrane Outer membrane Deoxyribonucleic acid(DNA)
线粒体的结构与功能:线粒体是含有双层膜结构的膜式细胞器
Mitochondria Ribosome ATP synthase particles Cristae DNA Is also attached inner membrane Inner membrane Granule ater Inner membrane membrane space C. Ophardt c 2006
MITOCHONDRIA INSIDE A CELL INSIDE THE MITOCHONDRION FAT SUGAR "INTERMEDIATES" ① Mitochondrial DNA Beta Oxidation Acid Cycle (Energy)
outer mitochondrial membrane inner mitochondrial membrane ATP synthal electron transport 2H20 H ATP OUT NAD'NADI TP ADP + P ADP + Pi citric acid cl acetyl CoA ate fatty acids py ruvate fatty acids FOOD MOLECULES FROM CYTOSOl Figure 14-10 Molecular Biology of the Cell 5/e(o Garland Science 2008)
outer mitochondrial membrane inner mitochondrial membrane ATP synthal electron transport chain H ATP OUT NAD'NADI TP ADP + P ADP + Pi citric acid cl cetyl CoA 生化反应(燃烧燃料) ate fatty acids ruvate fatty acids FOOD MOLECULES FROM CYTOSOl Figure 14-10 Molecular Biology of the Cell 5/e(o Garland Science 2008)
生化反应(燃烧燃料)
outer mitochondrial membrane inner mitochondrial membrane ATP synthal 电子传递 能量转换 electr transport H OUT NAD'NADH ATP TP ur+Pi ADP + Pi citric acid cl cetyl CoA 生化反应(燃烧燃料) ate fatty acids ruvate fatty acids FOOD MOLECULES FROM CYTOSOl Figure 14-10 Molecular Biology of the Cell 5/e(o Garland Science 2008)
生化反应(燃烧燃料) 电子传递, 能量转换
H H H ATP synthase MATRIX H H'O22H20 electron-transport chain ADP ATP inner membrane +p outer membrane Figure 14-14 Molecular Biology of the Cell 5/e(o Garland Science 2008)
化学渗透假说 Outer membrane Inter- membrane 4 HO >4H 2 H space ④t ODORa Inner Cyto- mitochon 从‖戏人k drial 4 H 2HO 4 Hb wHO 1202c2623 Matrix space 2-3 2-3 aePP Citric acid ATP NADH cycle H2O 10H B-Oxidation B Organization
化学渗透假说