An ecological approach tomicrobes and diseaseLS-HHMI OutreachProgram Summer WorkshopHarvard UniversityCambridge,MAJuly 10, 2008JonClardy,HarvardUniversityjon_clardy@hms.harvard.edu
An ecological approach to microbes and disease LS-HHMI Outreach Program Summer Workshop Harvard University Cambridge, MA July 10, 2008 Jon Clardy, Harvard University jon_clardy@hms.harvard.edu
Central dogma andbiological information flowDNARNAprotein
Central dogma and biological information flow DNA RNA protein
Small molecules and biological information flowNH2HCthiamineserotoninP20gH3smallDNARNAproteinmoleculesOHHOtestosteronerapamycinOHOCHOHO=estradiolOHHCOCH
Small molecules and biological information flow DNA RNA protein small molecules testosterone thiamine serotonin estradiol rapamycin N N S O P2O6H3 NH2 + N H HO NH2 OH HO OH O OH OCH3 O OH OCH3 O OCH3 O O O O N HO
RolesofsmallmoleculesDyingloblollypinesDendroctonusfrontalisSouthernpinebeetle(SPB)ImagesfromKierKlepzig(USDA-FS)andhttp://www.dartmouth.edu/~mpayres/photos.htm
Dying loblolly pines Roles of small molecules Images from Kier Klepzig (USDA-FS) and http://www.dartmouth.edu/~mpayres/photos.htm Dendroctonus frontalis Southern pine beetle (SPB)
Southern pine beetle (Dendroctonus frontalis)rice grainsouthernpinebeetleblackturpentinebeetle
southern pine beetle rice grain black turpentine beetle Southern pine beetle (Dendroctonus frontalis)
SPB attacks,pine counterattacksUGA0284024bTexasForestService(RonBillings)
SPB attacks, pine counterattacks Texas Forest Service (Ron Billings)
SPB callsforreinforcementsfrontalinUGA0284024bTexasForestService(RonBillings
SPB calls for reinforcements Texas Forest Service (Ron Billings) frontalin O O
Mass attack, victoryand spread001307UniversityofGeorgia(ChuckBargeron)UGA1247132GeorgiaForestryCommission(TerryPrice)VirginiaDepartmentofForestry(TimTigner）
Mass attack, victory and spread Georgia Forestry Commission (Terry Price) University of Georgia (Chuck Bargeron) Virginia Department of Forestry (Tim Tigner)
SPB gallery in the cambiumSPB larvaEntomocorticiumsp.(Es)ImagefromKierKlepzig(USDA-FS)
SPB gallery in the cambium SPB larva Entomocorticium sp. (Es) Image from Kier Klepzig (USDA-FS)
EntomocorticiumspSPBcarriesamutualisticfungusinthemycangium-aspecializedstructureinthefemale100
SPB carries a mutualistic fungus in the mycangium - a specialized structure in the female. Entomocorticium sp