Genetic evolution of H5N1 Jen-Ren Wang,Ph.D. Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University Department of Pathology,National Cheng Kung University Hospital National Health Research Institutes Tainan Virology Laboratory for Diagnosis and Research Department of Health,Taiwan Centers for Disease Control contract Virology Laboratory
Genetic evolution of H5N1 Jen-Ren Wang, Ph. D. • Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University • Department of Pathology, National Cheng Kung University Hospital • National Health Research Institutes Tainan Virology Laboratory for Diagnosis and Research • Department of Health, Taiwan Centers for Disease Control contract Virology Laboratory
Areas with confirmed human cases of H5N1 avian influenza since 2003* Statusas of1 March2008 e食ept 018 Areas with confirmed human cases All dates refer to onset of illness 89aa曲 669时 World Health Organization 18/Mar/2008
World Health Organization 18/Mar/2008
Time Line of Emergence of H5NI Influenza Virus 8: 启 12 68 ● 25 =每■■短■到■■量指数能应指后日回级组级细 18 ◆3 China Year 1996 1997 1998 2003 2004 2005 2006 Clade 2 Subclade 3 Webster,et al.N ENGL J MED.2006.355:2174-2177
Webster, et al. N ENGL J MED. 2006. 355:2174-2177
Spread of H5N1 Influenza Virus hin Webster G,et al.N ENGL J MED.2006.355:2174-2177
Webster G, et al. N ENGL J MED. 2006. 355:2174-2177
Genetic reassortment of H5N1 in Asia from 1999 to 2005 IIID ↓↓ (1m.ue:mm. NILIHtIDYIHIMD3 C4 IHNN CLI IIID 美 Peiris M.J.S.etal,007Clin Microbiol Rev 2 20(2,243-267
Genetic reassortment of H5N1 in Asia from 1999 to 2005 Peiris M. J. S. et al., 2007 Clin Microbiol Rev 20(2), 243–267
Phylogenetic relationships of the HA and NP genes of influenzaA viruses isolated in Indonesia and Vietnam HA NP ngha n2005 otype C uthern Chin Chin 0.01 0.01 Smith GJ,et al.Virology.2006.5;350(2):258-68
Phylogenetic relationships of the HA and NP genes of influenza A viruses isolated in Indonesia and Vietnam Smith GJ, et al. Virology. 2006. 5;350(2):258-68. HA NP
DK/ST4003/03 Clade ll, Cladel Phs44/04 L98 subclade l BVW/DS 304 /D5 0.005 0.05 Smith GJ,et al.Virology.2006.5;350(2):258-68
Clade II, Clade I subclade I Smith GJ, et al. Virology. 2006. 5;350(2):258-68
CHINA MYANMAR AOS Red River Delta Mekong River Delt NDONESIA Sumatra Flores Island ava B ABC West Timor AUSTRALIA Smith GJ et al. irology. 20 06 (2:258-68
Smith GJ, et al. Virology. 2006. 5;350(2):258-68
Genotypes of H5N1 influenza reassortants in Asia during2003-2005 CHINA Z+V) (Z+G) (Z+G+W INDONESIA Chen etal.,2006PNAS103,2845-2850
(Z) (Z+V) (Z) (Z) (Z) (Z+G) (Z+G+W) Genotypes of H5N1 influenza reassortants in Asia during 2003-2005 Chen et al., 2006 PNAS 103, 2845-2850
Emergence and predominance of an H5N1 variant in China since late 2005 Collection date No.of FJ-like viruses 2005 July-September 1133(3) October-December 72/136(53) 2006 January-March 90/113(80) April-June 103/108(95) Total 266/390(68) Smith,G.J.D.et al.(2006)Proc.Natl.Acad.Sci.USA103,16936-16941
Smith, G. J. D. et al. (2006) Proc. Natl. Acad. Sci. USA 103, 16936-16941 Emergence and predominance of an H5N1 variant in China since late 2005 Collection date No. of FJ-like viruses 2005 July–September 1/33 (3) October–December 72/136 (53) 2006 January–March 90/113 (80) April–June 103/108 (95) Total 266/390 (68)