I Systems Microbiology(13 Lectures 7hece∥ as a we∥}- stirred boc/ nem/ca/ reactor Introduction 2 Chemical kinetics, Equilibrium binding, cooperativity L3 Lambda phage L4 Stability analysis L5-6 Genetic switches

Alternative views on gradient sensing Postma and van hastert. 'a diffusion-translocation model for gradient sensing by chemotactic cells Biophys.J.81,1314(2001) Levchenko and Iglesias. Models of eukaryotic gradient sensing: applications to chemotaxis of amoeba and neutrophils

Review Turing-Gierer-Meinhardt models Local excitation, global inhibition 22r+hq

Wrapping up E coli chemotaxis (L7& L8) Main points of last 2 lectures L7: Biological background what is the function of the individual molecules L8: modeling of all possible chemotactic reactions why doesn't this model reproduce experimentally observed perfect adaptation

L14: 14 Lectures past and 1 1 to go Part 'The cell as a well-stirred bioreactor topICs Lambda phage lysis-lysogeny switch Synthetic genetic switch Switches as memory storage Chemotaxis: perfect adaptation or not? Synthetic genetic oscillators

Mathematical basis of stability analysis =f(x,y) system of two coupled differential equations y=g(x,y) step 1 find nullclines and fixed point(s)

麻省理工大学：《Systems Biology》Review lecture 2 Michaelis-Menten kinetics

Entropic elasticity Image removed due to copyright considerations. See Figure 19-50 in: Alberts, Bruce, et al. Molecular Biology of the Cell. 4th ed. New York: Garland Publishing, 2002 Image may be viewed online at the NIH's PubMed Bookshelf

Parasitology(寄生虫学), the study of parasites(寄生虫) and their relationships to the hosts(TE E), is one of the most fascinating areas of the biology. While it is entirely proper to classify many bacteria(细菌) and fungi(真菌) and all viruses as parasites

Molecular Biology of the Gene,5/e--- Watson et al.(2004) Part: Chemistry and Genetics Part ll: Maintenance of the Genome Part Ill: Expression of the Genome Part IV: Regulation Part V: Methods