Lipidemic modulating drugs Antiatherosclerotic agents Abnormal blood flow Plaque Narrowing of artery Narrowed Plaque artery
Lipidemic modulating drugs Antiatherosclerotic agents
Causes High blood cholesterol ■High blood pressure o Smoking o( Obesity Lack of physical activity
High blood cholesterol High blood cholesterol High blood pressure High blood pressure Smoking Smoking Obesity Obesity Lack of physical activity Lack of physical activity
section 1 introduction 1.atherosclerosis 2.the composition of blood lipid 口cholesteryl esters(CE,胆固醇酯) ▣triglycerides(TG,甘油三酯)， ▣cholesterol,.(Ch胆固醇 ▣phospholipids (PL磷脂) 口apolipoproteins(载脂蛋白)
section 1 introduction 1.atherosclerosis 1.atherosclerosis 2.the composition of blood lipid 2.the composition of blood lipid cholesteryl cholesteryl esters(CE esters(CE, 胆固醇酯 ) triglycerides (TG triglycerides (TG，甘油三酯), cholesterol, (Ch cholesterol, (Ch 胆固醇 ) phospholipids (PL phospholipids (PL磷脂） apolipoproteins apolipoproteins（载脂蛋白）
3.major lipoprotein classes: *chylomicron VLDL IDL LDL HDL 4.the action of lipoprotein in atherosclerosis formation VLDL,LDL,IDL,apoB HDL,apoA
3. major lipoprotein classes: 3. major lipoprotein classes: chylomicron chylomicron VLDL IDL LDL HDL VLDL IDL LDL HDL 4. the action of lipoprotein in atherosclerosis 4. the action of lipoprotein in atherosclerosis formation formation VLDL, LDL, IDL, VLDL, LDL, IDL, apoB HDL, apoA
4.forms of hyperlipoproteinemia form ipoprotein abnormality plasma lipid abnormality CM t TG TC LDL Tc Ib VLDL,LDL TGTC m IDL TGTC VLDL TG CM,VLDL
4. forms of hyperlipoproteinemia form ipoprotein ipoprotein abnormality abnormality plasma lipid abnormality plasma lipid abnormality I CM TG TC TG TC IIa LDL TC IIb VLDL, LDL VLDL, LDL TG TC TG TC III IDL TG TC TG TC IV VLDL TG V CM, VLDL CM, VLDL TG TC TG TC
section 2 lipidemic-modulating drugs Drugs which lower the TC and LDL 1.inhibitors of HMMG-CoA reductase Drugs: mevastatin(美伐他汀) lovastatin(洛伐他汀) pravastatin(普伐他汀) simvastatin(辛伐他汀) fluvastatin(氟伐他汀)
section 2 lipidemic-modulating drugs Drugs which lower the TC and LDL Drugs which lower the TC and LDL 1.inhibitors of HMG 1.inhibitors of HMG-CoAreductase reductase Drugs:mevastatin mevastatin (美伐他汀 ) lovastatin lovastatin (洛伐他汀 ) pravastatin pravastatin (普伐他汀 ) simvastatin simvastatin (辛伐他汀 ) fluvastatin fluvastatin (氟伐他汀 )
drugs which lower the TC and LDL 2.Bile acid-binding resins 胆汁骏结合树脂) Drugs:cholestyramine(考来烯胺) colestipol(考来替泊)
drugs which lower the TC and LDL 2.Bile acid 2.Bile acid -binding resins binding resins (胆汁酸结合树脂 胆汁酸结合树脂 ) Drugs : Drugs : cholestyramine cholestyramine (考来烯胺 ) colestipol colestipol (考来替泊 )
drugs which lower the TG and VLDL Phenyloxygen acid (fibrates) Drugs:gemfibrozil(吉非贝齐) benzafibrate(苯扎贝特) fenofibrate(非诺贝特)
drugs which lower the TG and VLDL Phenyloxygen Phenyloxygen acid (fibrates fibrates ) Drugs: gemfibrozil gemfibrozil (吉非贝齐) benzafibrate benzafibrate (苯扎贝特 ) fenofibrate fenofibrate (非诺贝特 )
Drugs which lower the TG and VLDL Nicotinic acid(烟酸 Pharmacological action (1)decrease VLDL,TG,LDL;increase HDL (2)inhibit platelet aggregation &(③)dilate vessel
Drugs which lower the TG and VLDL Nicotinic acid ( Nicotinic acid (烟酸 ) Pharmacological action Pharmacological action (1) decrease VLDL, TG, LDL; increase (1) decrease VLDL, TG, LDL; increase HDL (2) inhibit platelet aggregation (2) inhibit platelet aggregation (3) dilate vessel (3) dilate vessel
section 3 Antioxidants Probucol(普罗布考) 1.pharmacological action decrease TC,LDL-c,HDL-c protect LDL from hydroperoxidation. 2.Clinical use hypercholesterylemia
section 3 Antioxidants Probucol Probucol (普罗布考 ) 1.pharmacological action 1.pharmacological action decrease TC, LDL decrease TC, LDL -c, HDL - c protect LDL from protect LDL from hydroperoxidation hydroperoxidation . 2.Clinical use 2.Clinical use hypercholesterylemia hypercholesterylemia