Viral Hepatitis Yuan Zhe The First Affiliated Hospital Chongqing Medical University
Viral Hepatitis Yuan Zhe The First Affiliated Hospital Chongqing Medical University
Contents Viral etiology Epidemiology Pathogenesis Clinical manifestation Diagnosis Treatment Prevention guide
Contents Viral etiology Epidemiology Pathogenesis Clinical manifestation Diagnosis Treatment Prevention guide
THE VIRUS HAV:hepatitis A virus HBV:hepatitis B virus HCV:hepatitis C virus HDV:hepatitis D virus HEV:hepatitis E virus HGV:hepatitis G virus TTV:transfusion transmitted virus
THE VIRUS HAV: hepatitis A virus HBV: hepatitis B virus HCV: hepatitis C virus HDV: hepatitis D virus HEV: hepatitis E virus HGV：hepatitis G virus TTV： transfusion transmitted virus
Major Features of HAV Virion: Naked,spherical particle,diameter of 27nm Genome:Single-stranded linear RNA,7.5kb Genus:Heparnavirus,within the Picornaviridae family Stability:Room temp for 1 wk,85C for 1 sec, UV for 1 sec,in 70%alcohol for 3 min
Major Features of HAV Virion: Naked, spherical particle, diameter of 27nm Genome: Single-stranded linear RNA, 7.5kb Genus: Heparnavirus, within the Picornaviridae family Stability: Room temp for 1 wk, 85oC for 1 sec, UV for 1 sec, in 70% alcohol for 3 min
Major Features of HBV Virion: Enveloped,spherical particle,diameter of 42 nm,intermal core is 28 nm. Genome:3.2kb circular DNA,having four ORF in the complete strand,C,S,P and X genes. Genus: Hepadnavirus(HBV,WHV,GSHV,DHBV) Ag-Ab systems:HBSAg-Ab HBeAg-Ab HBcAg-Ab(IgG,IgM)
Major Features of HBV Virion: Enveloped, spherical particle, diameter of 42 nm, intermal core is 28 nm. Genome: 3.2kb circular DNA, having four ORF in the complete strand, C, S, P and X genes. Genus: Hepadnavirus(HBV, WHV, GSHV, DHBV) Ag-Ab systems: HBsAg-Ab HBeAg-Ab HBcAg-Ab(IgG, IgM)
HBV Stability Complete Condition Stable Inactivation Heat 60C for 4hr 100°Cfor10min
HBV Stability Complete Condition Stable Inactivation Heat 60oC for 4 hr 100oC for 10 min
Major Features of HCV Virion:Enveloped,spherical particle,diameter of 50-55 nm Nucleic acid:9.4 kb,a positive-stranded RNA molecule Genus:Flaviviridae family member Stability:Heat 60C for 10 hr,100C for 5min Formalin 1:1000,37℃，6hr Chloroform 10%-20%(vW),6hr
Major Features of HCV Virion: Enveloped, spherical particle, diameter of 50-55 nm Nucleic acid: 9.4 kb, a positive-stranded RNA molecule Genus: Flaviviridae family member Stability: Heat 60oC for 10 hr, 100oC for 5min Formalin 1:1000, 37oC, 6 hr Chloroform 10%-20%(v/v), 6 hr
Major Features of HDV Virion: HBsAg enveloped,spherical particle, diameter of 35-37 nm Genome: 1.78 kb,a negative-stranded, closed circular RNA molecule Stability: Heat 100C for 5min
Major Features of HDV Virion: HBsAg enveloped, spherical particle, diameter of 35-37 nm Genome: 1.78 kb, a negative-stranded, closed circular RNA molecule Stability: Heat 100oC for 5min
Major Features of HEV Virion: naked,spherical particle,diameter of 32~34 nm Genome:7.5 kb,a positive-stranded RNA molecule Genus: Indefinite Stability: sensitive to high temp,chloroform,etc
Major Features of HEV Virion: naked, spherical particle, diameter of 32~34 nm Genome: 7.5 kb, a positive-stranded RNA molecule Genus: Indefinite Stability: sensitive to high temp, chloroform, etc
Major Features of HGV Virion: Eenveloped virus Genome:9.1~9.4 kb,a positive-stranded RNA molecule Genus: Flaviviridae family Pathogenicity:Indefinite
Major Features of HGV Virion: Eenveloped virus Genome: 9.1~9.4 kb, a positive-stranded RNA molecule Genus: Flaviviridae family Pathogenicity: Indefinite
