Mitochondrial Permeability Transition Pore Gao Qin
Mitochondrial Permeability Transition Pore Gao Qin
多Structure of MPTP Causes and consequences of MPTP opening Effectors of MPTP
❖Structure of MPTP ❖Causes and consequences of MPTP opening ❖Effectors of MPTP
Mitochondria Inner Structure Inner Membrane Outer Membrane Cristae Matrix
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In 1976,Hunter and Haworth first characterized the mitochondrial permeability transition in beef heart mitochondria In 1987,Martin Crompton et al.implied that the pore is a unique molecular entity that allows the passage of any molecule of <1500daltons across the inner mitochondrial membrane
❖ In 1976, Hunter and Haworth first characterized the mitochondrial permeability transition in beef heart mitochondria. ❖ In 1987, Martin Crompton et al. implied that the pore is a unique molecular entity that allows the passage of any molecule of <1500daltons across the inner mitochondrial membrane
Models of MPTP structure Mitochondrial permeability transition pore (MPTP)is a non-specific pore which spans the inner and outer membrane. Two hypotheses about MPTP structure
❖ Mitochondrial permeability transition pore (MPTP) is a non-specific pore which spans the inner and outer membrane. ❖ Two hypotheses about MPTP structure Models of MPTP structure
The first: Three core components: VDAC (voltage-dependent anion channel) ANT (adenine nucleotide translocator) *CypD (cyclophilin D)exhibits peptidyl-prolyl cis-trans isomerase(PIPase)activity
The first: Three core components: ❖ VDAC (voltage-dependent anion channel) ❖ ANT (adenine nucleotide translocator) ❖ CypD (cyclophilin D) exhibits peptidyl-prolyl cis-trans isomerase(PIPase) activity
Bax PBR OM VDAC ANT IM CypD
Two conformations of ANT According to ATP/ADP-binding site m-conformation:on the matrix side of the inner membrane c-conformation:on the cytoplasmic side
Two conformations of ANT ❖ According to ATP/ADP-binding site m-conformation: on the matrix side of the inner membrane c-conformation: on the cytoplasmic side
"m"conformation "c"conformation CVP-D
Ca Atr