Effect of Heme Oxygenase-1 on the smooth muscle cells growth
Effect of Heme Oxygenase-1 on the smooth muscle cells growth
the biological function of heme oxygenase
the biological function of heme oxygenase
Heme oxygenase heme Fe2+ co Biliverdin-Bilirubin
Heme oxygenase + heme Biliverdin Bilirubin Fe2+ CO
three isoforms of heme oxygenase(HO) HO-1:an inducible isoform HO-2:a constitutive isoform HO-3:closely resembles HO-2
three isoforms of heme oxygenase (HO) HO-1 : an inducible isoform HO-2: a constitutive isoform HO-3: closely resembles HO-2
L-10 NO UV radition 15-PGJ2 hypoxia Heat shock proteins HO-1 Biliverdin co Protection
hypoxia UV radition IL -10 NO 15 -PGJ2 Heat shock proteins
Protection effect of HO-1 by many mechnisms Anti- inflammation Anti-apoptotisis Anti-proliferation
Protection effect of HO-1 by many mechnisms Antiinflammation Anti-apoptotisis Anti-proliferation
the effect of HO-1 on the smooth muscle cells growth
the effect of HO-1 on the smooth muscle cells growth
HO-1 gene deletion(Hmox1-/-)results in enhanced cell growth 500 ● Hmox1-/ 400 Hmox1+/+ 200 100 24 48 12 Time (hours)
Hmox1–/– Hmox1+/+ HO-1 gene deletion (Hmox1-/-) results in enhanced cell growth
Transfer AdHO-1 (adenovirus containing the rat HO-1 gene)to SMCs HO-11竹 AdHO-1 AdHO-1(MOI) 0125102050 SMC HO-1
+ SMC Transfer AdHO-1 (adenovirus containing the rat HO-1 gene) to SMCs AdHO-1 HO-1
Infection of SMCs with AdHO-1 inhibit the proliferative response to serum in a concentration- dependent manner 14A 20 B 15 10 0L52050L52050」 0L5205052050 AdGFP (MOI)AdHO-1 (MOI AdGFP (MOD AdHO-1(MOI) 2%serum 5%serum
2% serum 5% serum Infection of SMCs with AdHO-1 inhibit the proliferative response to serum in a concentrationdependent manner