ATP Sensitive Potassium Channel Guo Wei Zhejiang University School of Medicine
ATP Sensitive Potassium Channel Guo Wei Zhejiang University School of Medicine
Structure inward-rectifying potassium channel subunit(Kir):a pore Kir6.1 Kir6.2 sulfonylurea receptor(SUR):a regulatory SUR1 SUR2
Structure ◆inward-rectifying potassium channel subunit (Kir) : a pore ◆sulfonylurea receptor (SUR) : a regulatory Kir6.1 Kir6.2 SUR1 SUR2
Structure NBF I
Structure
Regulation the KATp channels are inhibited by direct ATP binding to the Kir pore-forming subunit,preventing K+flux across the membrane ◆ATP、Mg2+-ATP、ADP、Mg2+-ADP
Regulation ◆the KATP channels are inhibited by direct ATP binding to the Kir pore-forming subunit, preventing K+ flux across the membrane ◆ ATP、Mg2+ -ATP、ADP、 Mg2+ -ADP
Pharmacologic Regulation Openers:Pinacidil,cromakalim, nicorandil,diazoxide Blockers glibenclamide,5-hydroxy decanoate
Pharmacologic Regulation ◆Openers : Pinacidil, cromakalim , nicorandil, diazoxide ◆Blockers : glibenclamide , 5-hydroxy decanoate
ATP-sensitive potassium channel subtypes in the myocardium sarcolemma(sarcKATP)membrane the inner membrane of the mitochondria (mitoKATP)
ATP-sensitive potassium channel subtypes in the myocardium ◆sarcolemma (sarcKATP) membrane ◆the inner membrane of the mitochondria (mitoKATP)
sarcKATP unnecessary Shortening of the Inhibition of Ca2+ action potential overloading
sarcKATP Shortening of the action potential Inhibition of Ca2+ overloading It’s unnecessary
K1/2=840 sarcKATP umol/L K112 0.8umol/L
Diazoxide sarcKATP mitoKATP K1/2= 0.8µmol/L K1/2=840 µmol/L
It was indeed not the surface but the mitoKATp channel that was involved in cardioprotection
◆It was indeed not the surface but the mitoKATP channel that was involved in cardioprotection ！
Cardioprotection mechanism Opening the mitoKATP channel
Opening the mitoKATP channel Cardioprotection mechanism