Cardiovascular Changes in Diabetes Wang Hui-ping
Cardiovascular Changes in Diabetes Wang Hui-ping
Diabetes One of the most common metabolic diseases of our times Specific cardiovascular alterations are often associated with the progression of this disease. A major risk factor leading to increased cardiovascular mortality and morbidity
Diabetes One of the most common metabolic diseases of our times Specific cardiovascular alterations are often associated with the progression of this disease. A major risk factor leading to increased cardiovascular mortality and morbidity
The experimental diabetic-rat model Streptozotocin(链脲霉素)-induced diabetes Male SD rat (175-22 Intravenous tailvein i STZ:50-65mg/kg in ci Blood glucose measu 1,4(early),6,8,10
The experimental diabetic-rat model Streptozotocin（链脲霉素）-induced diabetes Male SD rat (175-220g) Intravenous tailvein injection, ip STZ: 50-65mg/kg in citrate buffer 0.1mol/L, pH 4.5 Blood glucose measurement: glucometer(Upjohn) 1,4 (early), 6, 8, 10, 16(chronic)wk
The experimental diabetic-rat model Alloxan(四氧嘧啶)-induced diabetes Rat(190g-220g) Intravenous tailvein injection Alloxan:200mg/kg(腹腔注射) Blood glucose measurement:邻甲苯胺法 血(serum)糖值》13.9mmol/L
The experimental diabetic-rat model Alloxan（四氧嘧啶）-induced diabetes Rat (190g-220g) Intravenous tailvein injection Alloxan: 200mg/kg (腹腔注射) Blood glucose measurement: 邻甲苯胺法 血(serum)糖值》13.9mmol/L
The experimental diabetic-rat model The high glucose incubation model in vitro Normal glucose levels:+5-11mmol/L Diabetic glucose levels:>=30mmol/L
The experimental diabetic-rat model The high glucose incubation model in vitro Normal glucose levels: 5-11mmol/L Diabetic glucose levels: >=30mmol/L
The experimental diabetic-rat model myocytes at cardiomyocytes myocytes from adult rats with either normal(5.5 mM) 25um cose
The experimental diabetic-rat model High glucose-treated myocytes Incubating neonatal rat cardiomyocytes Isolated Ventricular myocytes from adult rats were cultured for 24 h with either normal (5.5 mM) or high (25.5 mM) glucose
Histopathology typical dia 个Collage Cardion Alteration myofibers Myofibri ↓Volume 个Mitoch
Histopathology typical diabetic alterations Collagen content, vacuolation, lipid drops Cardiomyocyte diameter Alteration in myofilaments and Z-lines of myofibers Myofibrillary degeneration Volume fraction of myofibrils, SR and t-tubules Mitochondrial size and volume fraction
Histopathology Oxidative damage (T ROS formation) Apoptosis Hyperglycemia->local renin-angiotensin system(+)→AngIⅡ个→(+)endogenous cell death pathway
Histopathology Oxidative damage ( ROS formation) Apoptosis Hyperglycemia→local renin-angiotensin system(+) →Ang II →(+) endogenous cell death pathway
Diabetes-induced cardiac mechanical dysfunctions--organ level Depressed c Slow relaxat Increased CH HR ↓Density c Supersensit effects
Diabetes-induced cardiac mechanical dysfunctions--organ level Depressed contraction Slow relaxation Increased Chamber volume HR Density of myocardial -AR Supersensitivity to negative chronotropic effects
Diabetes-induced cardiac mechanical dysfunctions--cell level PS ±dL/dt Prolonged duration of shortening Prolonged duration of relengthening
Diabetes-induced cardiac mechanical dysfunctions--cell level PS dL/dt Prolonged duration of shortening Prolonged duration of relengthening