Calcium Cycling in Cardiac Cells Lin Guo-hua
Calcium Cycling in Cardiac Cells Lin Guo-hua
Cardiac E-C coupling 3Na Sarcolemma NCX Ca Ca SR OSERCA Ca ◆ Myofilaments Ca [Cal (NCX) 3Na AP Contraction 200ms
Cardiac E-C coupling
Slow or L-type Ca2+Channels (DHPRs)
Slow or L-type Ca2+ Channels (DHPRs)
L-type Ca2+Channels 02
L-type Ca2+ Channels
Ca2+Release Channel of the Sarcoplasmic Reticulum (Ryanodine Receptor) A KBP12 RyR2 102030am4000 Signaling Complex(SC)domain
Ca2+ Release Channel of the Sarcoplasmic Reticulum (Ryanodine Receptor)
cardiac ryanodin receptor Calmodulin Sorcin cytoplasm FKBP12/12.6 P PP1 RyR1/2 【mAKAP PKA PP2a Triadin Ca2+ Ca2+ Ca2 Calsequestrin SR lumen Ca2Ca2
cardiac ryanodin receptor
Physiological and pathophysiological regulation Physiological Non-failing heart netic stimulation Failing heart SERCA SR Ca2+: "normal "increased" decreased cw none/minimal ncreas
Physiological and pathophysiological regulation
Ca2+Pump of the Sarcoplasmic Reticulum (SERCA)
Ca2+ Pump of the Sarcoplasmic Reticulum (SERCA)
SERCA (A)E2Tg (B)E1Ca2 N domain A domain
SERCA
SERCA-PLN complex L89
SERCA-PLN complex