Flavonoids A traditional Chinese medicine used in modern science
A traditional Chinese medicine used in modern science Flavonoids
Introduction Flavonoids are nearly ubiquitous in plants and are consumed regularly with the human diet Certain plants and spices containing flavonoids have been used for thousands of years in traditional Eastern medicine They are usually subdivided into flavanols anthocyanidins flavones flavanones chalcones
Introduction Flavonoids are nearly ubiquitous in plants and are consumed regularly with the human diet Certain plants and spices containing flavonoids have been used for thousands of years in traditional Eastern medicine They are usually subdivided into flavanols anthocyanidins flavones flavanones chalcones
The flavonoids display a remarkable array of biochemical and pharmacological actions
The flavonoids display a remarkable array of biochemical and pharmacological actions
Direct effect on mitochondrial calcium uniporter
Direct effect on mitochondrial calcium uniporter
effects of several of the most naturally abundant flavonoids on mitochondrial Ca2+uptake in permeabilized HeLa cells Ca2+3.5uM Ca2+3.5uM 300 Kaempferol Quercetin m 40 HM 1 20 HM 5uM 200 100 WTM ANA Control 1min Ca2+3.5μM Ca2+3.5uM 3001 40%7 200 Genistein w55 M Genistin 屋网 cont女ol C ontrol
effects of several of the most naturally abundant flavonoids on mitochondrial Ca2+ uptake in permeabilized HeLa cells
Concentration dependence of the activation of mitochondrial Ca2+ uptake by several natural flavonoids 201 ●-Kaempferol 量-Quercetin 15 盒Genistin Genistein 10 5 5 10 50 Concentration(uM)
Concentration dependence of the activation of mitochondrial Ca2+ uptake by several natural flavonoids
Reversible activation of mitochondrial Ca2+uptake by kaempferol in permeabilized cells Ca2+2.5uM 100 Kaempferol Kaempferol 80 (wr)W[+zeo] 60 40 20 2min
Reversible activation of mitochondrial Ca2+ uptake by kaempferol in permeabilized cells
Ca 3.5 uM 160 Inhibition by Ru360 of the 120 mitochondrial % Kaempferol Ca2+uptake induced by % kaempferol and p-wwhuwwh SB202190 Kaempferol+Ru360 160 Ca 3.5 uM 2四 SB202190 nhwwnweae wwwwwmhhymuhkholy 1min SB202190+Ru360
Inhibition by Ru360 of the mitochondrial Ca2+ uptake induced by kaempferol and SB202190
Ca2+3.5uM Effect of the absence of 300 SB的 Ca2+3.5uM ATP in the activation of mitochondrial w Genistein 1mM No ATP ATP SB10 Ca2+uptake by SB1 1mM ADP genistein or Ge stein 100 SB202190 Control SB1 0 1 min Control 4 1mM ATP No ATP,1mM ADP 3 2 1 Control Genistein Control Genistein
Effect of the absence of ATP in the activation of mitochondrial Ca2+ uptake by genistein or SB202190
attenuate apoptosis and protein oxidation in neuronal cell lines
attenuate apoptosis and protein oxidation in neuronal cell lines