Role of Adenosine Receptor in Ischemic Preconditioning
Role of Adenosine Receptor in Ischemic Preconditioning
Basic Knowledge 1.what is ischemic preconditioning (IPC)? A phenomenon by which a brief episodes of myocardial ischemia increases the ability of the heart to tolerate a subsegent prolonged period of ischemic injury. 2.Early phase (classical'conditioning )and delayed phase ('second window'of protection) Early phase appears immediately;delayed phase appears at 24,48,72 hours following brief periods of preconditioning ischemia
Basic Knowledge 1.what is ischemic preconditioning (IPC)? A phenomenon by which a brief episodes of myocardial ischemia increases the ability of the heart to tolerate a subseqent prolonged period of ischemic injury. 2. Early phase (‘classical’conditioning ) and delayed phase (‘second window’of protection) Early phase appears immediately; delayed phase appears at 24,48,72 hours following brief periods of preconditioning ischemia
3.Triggers of ischemic preconditioning 1)Receptor dependent triggers A.Adenosine receptors B.Opioid receptors 2)Receptor independent triggers A.Nitric oxide B.Free radicals
3.Triggers of ischemic preconditioning 1) Receptor dependent triggers A. Adenosine receptors B. Opioid receptors 2) Receptor independent triggers A. Nitric oxide B. Free radicals
Subtypes and Distributing of Adenosine receptors
Subtypes and Distributing of Adenosine receptors
.Al adenosine receptor (A1AR) .AlAR is found in the myocytes and in the vascular smooth muscle. .A2 adenosine receptor (A2AR) .A2AR including A2A and A2B,can be found in the endothelium and the vascular smooth muscle .A3 adenosine receptor (A3AR) .Locate in the plasmatic membrane of the myocytes
•A1 adenosine receptor (A1AR) •A1AR is found in the myocytes and in the vascular smooth muscle. •A2 adenosine receptor (A2AR) •A2AR including A2A and A2B,can be found in the endothelium and the vascular smooth muscle . •A3 adenosine receptor (A3AR) •Locate in the plasmatic membrane of the myocytes
Structures of Adenosine Receptors
Structures of Adenosine Receptors
The Human A1Adenosine Receptor The Human A2A Adenosine Receptor The Human A3Adenosine Receptor The Human A2B Adenosine Receptor Fig.1.Sructures ofadenosine receptor
Fig.1.Sructures of adenosine receptor
Adenosine receptors are G- protein coupled receptors
Adenosine receptors are Gprotein coupled receptors
Adenosine Receptor Coupling Adenosine C82 2A G. Adenylate cyclase Inhibit Stimulate Protein Kinase Cyclic AMP ATP Vasodilation Fig.2.Adenosine receptor subtypes and their coupled G-proteins
Fig.2. Adenosine receptor subtypes and their coupled G-proteins
Al Adenosine Receptor Participates in Early Phase of Ischemic Preconditioning
A1 Adenosine Receptor Participates in Early Phase of Ischemic Preconditioning