⑧柴德案寶 求鶉求新 核受体基因表达调控 Recent Research on Gene Expression Regulation of Nuclear Receptors CB el:752641(o);E-mail:binnchen@tom.com
THIRD MILITARY MEDICAL UNIVERSITY COLLEGE OF BASIC MEDICAL SCIENCES CB Tel:752641(O); E-mail: binnchen@tom.com 核受体基因表达调控 Recent Research on Gene Expression Regulation of Nuclear Receptors
核受体与临床疾病发病与治疗 ■神经系统疾病 神经退行性变,慢性炎症( PPARY),疼痛抑郁症 阿尔茨海默病(ER) 代谢性疾病 ∏型糖尿病、高脂血症、肥胖、高血压、脂肪 肝、肿瘤、炎症(免疫)性疾病、水盐电解质 代谢紊乱等 血液系统疾病 白血病(RXR,ER)
THIRD MILITARY MEDICAL UNIVERSITY COLLEGE OF BASIC MEDICAL SCIENCES 核受体与临床疾病发病与治疗 ◼ 神经系统疾病 ◼ 神经退行性变,慢性炎症(PPARΥ),疼痛,抑郁症 、阿尔茨海默病(ER) ◼ 代谢性疾病 ◼ II型糖尿病、高脂血症、肥胖、高血压、脂肪 肝、肿瘤、炎症（免疫）性疾病、水盐电解质 代谢紊乱等 ◼ 血液系统疾病 ◼ 白血病(RXR,ER)
Outline Nuclear Receptor Pathway Hotspot in nrs research a Basic medicine(case D) Translational Medicine(case D) Applied basic research(case lly)
THIRD MILITARY MEDICAL UNIVERSITY COLLEGE OF BASIC MEDICAL SCIENCES ◼ Nuclear Receptor Pathway ◼ Hotspot in NRs research ◼ Basic Medicine (case I) ◼ Translational Medicine (case II) ◼ Applied Basic Research (case III) Outline
Ervironmental and developmental signals Actvaton Enhancer egion TBP Pol TATA HAA N box Initiation Site
THIRD MILITARY MEDICAL UNIVERSITY COLLEGE OF BASIC MEDICAL SCIENCES
Enhancer Activator DNA Coactivator TES RNA POl
THIRD MILITARY MEDICAL UNIVERSITY COLLEGE OF BASIC MEDICAL SCIENCES
Nuclear receptors 学术关注度(1996-2008) 关键词搜索:核受体 197 1999 2001 2002 2005 学术关注度(1996-2008) 关键词搜索:转录因子 1998 1999 21 004 00s 2007
THIRD MILITARY MEDICAL UNIVERSITY COLLEGE OF BASIC MEDICAL SCIENCES 核受体超家族是一类配体依赖性 转录因子，其成员广泛介导了与真核细 胞生长、发育和内环境稳定相关基因的 表达。 1、类固醇激素及其受体的作用机制 2、核受体超家族的组成和结构 Nuclear receptors 学术关注度（1996-2008） 关键词搜索：核受体 学术关注度（1996-2008） 关键词搜索：转录因子
inhibitory hormone-binding site protein complex COOH transcription activating domain H2N DNA-binding domain I hinge region steroid hormone DNA-binding site exposed H COOH
THIRD MILITARY MEDICAL UNIVERSITY COLLEGE OF BASIC MEDICAL SCIENCES
Nuclear Hormone Receptor NUCLEUS (inactive) INACTIVE GENE Hormone Promoter Response CYTOSOL Element A Nuclear Hormone Receptor H。mone receptor dimer mRNA synthesis BLOOD Steroid Homone Control of Gene transcription
THIRD MILITARY MEDICAL UNIVERSITY COLLEGE OF BASIC MEDICAL SCIENCES
CHOH HC 表6-12类固醇激素受体超家族的组成及性质 受体名称 分子量组成氨基因大小外显 与HSH90 kD基酸数(M)千数染色体定位细胞定位 结合 糖皮质激素受体CR 777 9 胞浆/核 盐皮质激素受体MR 胞浆/核 ●黄体素受体FR(A) 79 934 q22胞浆核 雄激素受体AR 98 918 >908Xq2-1浆/核 ●雌激素受体ER 595 胞浆/核 t,25(OH)2D受体VDR55427459 胞浆/核 T3受体T3Ral 40 I7q1-21胞浆/核 TRBI 52 456 >250 视黄酸受体RAR 17 (atRA)RAR &1 RAR 12 (9cRA)RXRo 467 RXRB 410 核核核核核核核 RXR 463
THIRD MILITARY MEDICAL UNIVERSITY COLLEGE OF BASIC MEDICAL SCIENCES
Nuclear Receptor Superfamily AB D E DNA Ligandb-C AF-1 CTE DIMERIZATION AF-2 Steroid Receptors RXR Heterodimers TaR thyroid hormone d GR glucocorticoid RAR all-trans RA MR mineralcorticoid RXE R VDR 1,25-(OH)2VD PR progesterone PPAR a fatty acids AR androgen PPARY 15d-△12,14PGJ ER estrogen EcR ecdysone FXR bile acids CAR androstane LXR oxysterol PXR/SXR xenobiotics Dimeric Orphan Receptors Monomeric /Tethered Orphan Receptors RXR 9-cis RA NGFI-B COUP RXR SF-1 HNF-4 Rev-erb TR2 ROR TLX ERR GCNF
THIRD MILITARY MEDICAL UNIVERSITY COLLEGE OF BASIC MEDICAL SCIENCES