GMBD Bioinformatics Core推廣課程 T81 Tumor-associated gene (TAG):a specialized database for cancer research 利用生物資部學的分析來找尋新穎癌症相 關基因之研究
GMBD Bioinformatics Core 推廣課程 利用生物資訊學的分析來找尋新穎癌症相 關基因之研究 Tumor-associated gene (TAG): a specialized database for cancer research
GMBD Bioinformatics Core推廣課程 T81 Carcinogenesis Initiation Promotion Progression Repair Apoptosis Apoptosis DNA Damage Proliferation Proliferation Normal Initiated Focal Lesion Cancer cell cell
GMBD Bioinformatics Core 推廣課程 Carcinogenesis Normal cell Initiated cell Focal Lesion Cancer Initiation Promotion Progression
GMBD Bioinformatics Core推廣課程 T81 Oncogene A proto-oncogene can be activated by Genetic alterations (point mutation or translocation) Translocation of the ABL proto-oncogene (chr.9)to the BCR gene (chr.22)produces a BCR/ABL fusion protein resulting in Chronic Myelogenous Leukemia. (Rowly Nature1973) Increasing the number of copies of the proto- oncogene (amplification)
GMBD Bioinformatics Core 推廣課程 Oncogene ✓ Genetic alterations (point mutation or translocation) Translocation of the ABL proto-oncogene (chr. 9) to the BCR gene (chr. 22) produces a BCR/ABL fusion protein resulting in Chronic Myelogenous Leukemia. (Rowly Nature1973) ✓ Increasing the number of copies of the protooncogene (amplification) A proto-oncogene can be activated by
GMBD Bioinformatics Core推廣課程 reilumor suppressor gene A TSG can be inactivated by Genetic alterations (point mutation or methylation) Decreasing the number of copies of the tumor suppressor gene (functional haploinsufficiency) Reduction of p53 dosage can promote cancer formation. (Venkatachalam et al.1998)
GMBD Bioinformatics Core 推廣課程 A TSG can be inactivated by ✓Genetic alterations (point mutation or methylation) ✓Decreasing the number of copies of the tumor suppressor gene (functional haploinsufficiency) Reduction of p53 dosage can promote cancer formation. (Venkatachalam et al. 1998) Tumor suppressor gene
GMBD Bioinformatics Core推廣課程 到 Hypothesis All tumor-associated genes share common functional domains thus the annotation of known oncogenes or tumor suppressor can help to identify novel genes with the same or similar functions
GMBD Bioinformatics Core 推廣課程 Hypothesis All tumor-associated genes share common functional domains thus the annotation of known oncogenes or tumor suppressor can help to identify novel genes with the same or similar functions
GMBD Bioinformatics Core推廣課程 T81 Objective To identify novel tumor-associated genes based on computational strategy Establish a tumor-associated gene (TAG)database and build a user- friendly web interface for searching and analysis of TAG information Define oncogene/TSG signature domain profiles and apply the profiles to search for novel TAGs
GMBD Bioinformatics Core 推廣課程 Objective To identify novel tumor-associated genes based on computational strategy ✓ Establish a tumor-associated gene (TAG) database and build a userfriendly web interface for searching and analysis of TAG information ✓ Define oncogene/TSG signature domain profiles and apply the profiles to search for novel TAGs
GMBD Bioinformatics Core推廣課程 Flow Chart T菜 Text mining Information retrieval Gene-related:GeneCards,Entrez Gene. Gene Ontology Protein-related:SwissProt,InterPro Collecting and Extracting System TAG Database (519 genes) Oncogene:198;Tumor suppressor gene:170;Other:151 Search by Text Search Oncogenic Search for Non- chromosome domain analysis TAG gene
GMBD Bioinformatics Core 推廣課程 Collecting and Extracting System Information retrieval Gene-related: GeneCards, Entrez Gene, Gene Ontology Protein-related: SwissProt, InterPro Text mining TAG Database (519 genes) Oncogene: 198; Tumor suppressor gene: 170; Other:151 Text Search Flow Chart Oncogenic domain analysis Search by chromosome ✓ GeneCards is a database of human genes, their products and their involvement in diseases. It offers concise information about the functions of all human genes. ✓ Entrez Gene is a searchable database of genes, from RefSeq genomes, and defined by sequence and/or located in the NCBI Map Viewer. ✓ Gene Ontology (GO) project is a collaborative effort to address the need for consistent descriptions of gene products in different databases. ✓ SwissProt is a curated protein sequence database that provides a high level of annotation, a minimal level of redundancy and a high level of integration with other databases. ✓ InterPro is an integrated documentation resource for protein families, domains and sites. It combines a number of databases that including Gene3D, PANTHER, PIRSF, Pfam, PRINTS, PROSITE, SMART, SUPERFAMILY, TIGRFAMs and ProDom. Search term for PubMed ✓ Keywords: Oncogene, Tumor suppressor gene, Oncogenesis ✓ Fields: Title, Abstract ✓ Publication date: 1970~2004 ✓ Species: Human Collecting and Extracting System Information retrieval Gene-related: GeneCards, Entrez Gene, Gene Ontology Protein-related: SwissProt, InterPro Text mining TAG Database (519 genes) Oncogene: 198; Tumor suppressor gene: 170; Other:151 Text Search Oncogenic domain analysis Search for NonTAG gene Search by chromosome
GMBD Bioinformatics Core推廣課程 TgI如何使用NCKU TAG database 網址：http:/www.binfo.ncku.edu.tw 研究資源→應用資源→TAG Database Binfo 立成功大學生物資凯中心 NCKU Bioinformatics Center 首頁(Home)l简介(Introdaction)I本中心最移(Smce)I研究資源(Resources)l相附速结(Links)1意見留言(Contact) ⊙應用資源 Vector NTI IB敏益下恭 NCKU BLAST NCKU SNP Detabase 成功大學前瞻生物 at Masher Ser 60608) 成功大学生物科TAG Database 婚生物程學科學研 封會，微精多位名 ~more 點選此連結
GMBD Bioinformatics Core 推廣課程 如何使用 NCKU TAG database 網址：http://www.binfo.ncku.edu.tw 點選此連結 研究資源 → 應用資源 → TAG Database
GMBD Bioinformatics Core推廣課程 NCKU TAG Database首頁 Binfo 。圆立成功大學生物資訊中心 NCKU Bioinformatics Center Oncogenic Domain 分析介面 umor Associated Gene 8 Oncogenic Domain Analysis Text Search List by Chromosome Non-TAG gene search The completion of human genome se nd analyze genes est through the use of computational ap n ar tum related gene en TA Non-TAG Gene database 文字搜募界面 以染色體為列表 facik cancer re ach 搜募界面 semi atic inf of th reso d store in the TAG database.At current stage,476 TAGs including 164 oncogenes,161 tumor suppressor gene genes related to oncogenesis were collected.Information collected in TAG database can be browsed TAG Database簡 h nalysis"can analyze oncogenic pote 寫信給成大生 回成功大學生物資 介 lated from the TAG proteins.This stud 訊中心首頁 NRPGM)and personnel from Bioinformat 物資部中心 National Cheng Kung University,Taiwan
GMBD Bioinformatics Core 推廣課程 NCKU TAG Database 首頁 回成功大學生物資 訊中心首頁 寫信給成大生 物資訊中心 Oncogenic Domain 分析介面 Non-TAG Gene 搜尋界面 TAG Database 簡 介 文字搜尋界面 以染色體為列表
GMBD Bioinformatics Core推廣課程 TEI TAG搜尋介面：一、利用染色體位置 1.點選你要搜尋的染色體圖示，在此以染色體17為例 List by Chromosome TAG web site designed and s orted by Dillon Chan Last Modified:2006/6/12 Counter:2615
GMBD Bioinformatics Core 推廣課程 TAG 搜尋介面: 一、利用染色體位置 List by Chromosome 1. 點選你要搜尋的染色體圖示，在此以染色體17為例