Development of the 8 Hematopoietic System athe Introduction of Anemia The department of Pediatric Hematology/Oncology, Dr Jie yu, MD. Associate Professor
Development of the Hematopoietic System & the Introduction of Anemia The department of Pediatric, Hematology/Oncology, Dr.Jie Yu, MD. Associate Professor
Contents Development of hematopoietic system Hematopoietic organs Hematopoietic blood cells .. Characteristic of cell counts and hemoglobin RBC and Hb level Hemoglobin WBC/Platelet/blood volume · Anemia
Contents • Development of hematopoietic system – Hematopoietic organs – Hematopoietic blood cells • Characteristic of cell counts and hemoglobin – RBC and Hb level – Hemoglobin – WBC/Platelet/Blood volume • Anemia
Development of Hematopoietic System
Development of Hematopoietic System
in the embryo and fetus aconstant changes characterize eall phases of hematopoiesis
i n t h e e m b r y o a n d f e t u s , c o n s t a n t c h a n g e s c h a r a c t e r i z e a l l p h a s e s o f h e m a t o p o i e s i s
Development of Hematopoietic Organs Fetal hematopoiesis Mesoblastic hematopoiesis Hepatic hematopoiesis Myeloid Hematopoiesis Hematopoiesis after birth
Development of Hematopoietic Organs • Fetal hematopoiesis – Mesoblastic Hematopoiesis – Hepatic Hematopoiesis – Myeloid Hematopoiesis • Hematopoiesis after birth
Table 1. Fetal Hematopoiesis SITES TIME PRODUC Mesoblastic Yolk Sac 10-14th day Erythroid hematopoisis 3-4wk: primitive blasts 10-12wk ceased e Hepatic Liver 6-8wk appear Erythroid hematopoiesis 12-16wk. active 6mo: diminish/ stop at birth e Myeloid B one 4mo start Erythroid e hematopoiesis marrow 6mo: increase/steady Neutrophils after birth: the only Macrophages
SITES TIME PRODUC Measoblastic hematopoisis Yolk Sac 10-14th day 3-4wk:primitive blasts 10-12wk:ceased Erythroid Hepatic hematopoiesis Liver 6-8wk:appear 12-16wk:active 6mo:diminish/ stop at birth Erythroid Myeloid hematopoiesis Bone marrow 4mo:start 6mo:increase/steady after birth: the only Erythroid Neutrophils Macrophages Table 1. Fetal Hematopoiesis
e Development of Hematopoietic Organs Fetal hematopoiesis Hematopoiesis after birth Bone marrow hematopoiesis Extrmedullary hematopoiesis
Development of Hematopoietic Organs • Fetal hematopoiesis • Hematopoiesis after birth – Bone marrow hematopoiesis – Extrmedullary hematopoiesis
e Development of Hematopoietic Organs Hematopoiesis after birth Bone marrow hematopoiesis All blood cells are produced in the marrow after 2nd trimester Newborn and early infancy: red marrow 5-7yr: yellow marrow Extrmedullary hematopoiesis
Development of Hematopoietic Organs • Hematopoiesis after birth – Bone marrow hematopoiesis • All blood cells are produced in the marrow after 2nd trimester • Newborn and early infancy: red marrow • 5-7yr : yellow marrow – Extrmedullary hematopoiesis
e Development of Hematopoietic Organs Hematopoiesis after birth Bone marrow hematopoiesis Extramedullary hematopoiesis In diseases status: red cell production hematopoietic tissue↑ blood production expands to replace fatty marrow ood ce lls production extends to extramedullary sites liver and spleen)
Development of Hematopoietic Organs • Hematopoiesis after birth – Bone marrow hematopoiesis – Extramedullary hematopoiesis • In diseases status: red cell production hematopoietic tissue. • blood production expands to replace fatty marrow. • blood cells production extends to extramedullary sites ( liver and spleen)
