第三章生物信息学网络资源 NCB简介
第三章 生物信息学网络资源 生物信息学网络资源 (1) NCBI简介
National Center for Biotechnology Information(NCBI) www.ncki.nlm.nihgov
National Center for Biotechnology Information (NCBI) www.ncbi.nlm.nih.gov
Entrez系统 NCB综合数据库 美国国家生物技术信息中心( National Center for biotechnology Information fa] 称NCBI)创建于1988年。 ●1991年,NCB|开发了 Entrez数据库查询系 统,用于对 Gen Bank等分子生物学和生物 医学文献摘要( Medline)等数据库的査询 ( Schuler et al,1996)
Entrez系统 NCBI综合数据库 z 美国国家生物技术信息中心 美国国家生物技术信息中心(National (National Center for Biotechnology Information Center for Biotechnology Information，简 称NCBI）创建于1988年 。 z 1991年，NCBI开发了Entrez数据库查询系 统，用于对GenBank GenBank等分子生物学和生物 等分子生物学和生物 医学文献摘要(Medline) (Medline)等数据库的查询 等数据库的查询 (Schuler et al, 1996) (Schuler et al, 1996)
Entrez全球搜索引擎 3Entrez cross-database search-Microsoft Internet Explorer x 文件)编辑()查看(收藏(A)工具(T帮助 中后退·中,国搜索收藏夹守媒体卧·目 地址p)圈]http://www.ncbi.nlm.nihgov/entrezJindex.html ◇转到链接 NCBI D, Entrez, The Life Sciences Search Engine HOME SEARCH SITE MAPPubMed Entrez Human GenomeGenBank-Map ViewerBLAST Search across databases LGO CLEAR He Welcome to the new Entrez cross-database search page PubMed: biomedical literature citations and abstracts 2 B Books: online books OMIM: Online Mendelian Inheritance in PubMed Central: free, full text journal Man article 大 w Site Search: NCBI web and FTP sites D Nucleotide: sequence database UniGene: gene-oniented clusters of 出 (GenBank 2A transcript sequences Protein: sequence database CDD: conserved protein domain database 2 6 3D Domains: domains from Entrez Genome: whole genome sequences Structure Structure: three-dimensional
Entrez跨库检索 fEntrezcross-database search -Microsoft Internet Explorer 文件()编辑巨查看()收减(A工具(T帮助H 中后退 ④的备②魂宗国收寐守煤体④··目以 地址CD)hp:www.ncb.nin.rih,9joqueryqueryfcc 转到娃接 NCBI Entrez, The Life Sciences Search Engine HOME SEARCH SITE MAP-PubMed Entrez Human Genome GenBank Map vieperBLAST Search across databases human antioncogene LGo CHop 20258 pubMed: biomedical literature citations and abstracte 0 BOoks: online books OMIM: Online Mendelian 772 pubMed Central: tree, tull text 2大 journal articles Inheritance in Man 1686w site search: ncBI web and FTp 2时3435色出四时团 Protein: sequence database 249 CDD: conserved protein domain database 39(H)sequences ②2201 3D Domains: domains from Entrez structure cture thre estrimenesona@1 55142P data s:a> and e图
Entrez用途 ·检索大分子生物学数据 ·获取 GenBank,EMBL等数据库的核酸序 列 获取SwⅰSS-port,P|R,PRF,PDB等蛋白质序 列;从核酸序列翻译到蛋白质的序列; ·获取基因和染色体图谱;蛋白质三维结构 数据及大分子模式(MDB)等其他生物信 息数据库检索 · PubMed书目文献数据
Entrez系统的使用方法
Entrez系统的使用方法 系统的使用方法
地址①)htt://www.ncbi.nimnihgov ˇ囝转到 NCBI National Center for Biotechnology Information National Library of Medcine National Inst itutes of Health PubMed All Databases BLAST OMIM Books Tax Browser Structure Search All Databases SITE MAI What does Ncbl do? Hot Spots Resource Guide Established in 1988 as a national resource for 'Assembly Archive About NCBI molecular biology information, NCBI creates public databases, conducts research in Clusters of An introduction to NCBI computational biology, develops software orthologous groups tools for analyzing genome data, and P Coffee Break GenBank disseminates biomedical information all for the better understanding of molecular Genes Disease Sequence submission support processes affecting human health and NCBI Handbook and software disease. More Electronic PCR Literature WHole Genome Association Entrez Home PubMed, OMIM, The NCBI whole Genome Association(UGA) resource Entrez Tools I provides researchers with access to genotype and PubMed Central associated phenotype information that will help lucidate the link between genes and disease. For/)Gene expression more information, click here to see the the WGA omnibus(GEO Molecular databases resource page and click here to read the press release. Human get resources structures. and taxonomy 1 Billion Live Traces Influenza Virus The Trace Archive of sequencing traces has Resource Genomic eached 1 billion live traces from over 480 organisms. For more information about the Trace www.ncbi.nim.nihgov
www.ncbi.nlm.nih.gov
D NCBI National Center for Biotechnology Information National Library of Medicine National Institutes of healtl PubMed All Databases BLAST OMIM Books Tax Browser Structure Search PubMed for
NCBI National Center for Biotechnology Information National Library of Medicine National Institutes of Health PubMed All Databases BLAST OMIM Books Tax Browser Structure Search PubMed for All Database integrates the scientific literature DNA and protein sequence databases 3d protein structure data population study data sets assemblies of complete genomes
All Database integrates… • the scientific literature; • DNA and protein sequence databases; • 3D protein structure data; • population study data sets; • assemblies of complete genomes