ZosterHerpes业蓝W
Herpes Zoster
DefinitionHerpesiscausedzosterby(VZV)Varicella - Zosterviruswithinclassicallyunilaterallyoccursthe distribution of asensorynerve.beingbyclusteredcharacterizedandvesiclesconsiderableneuralgia
Definition Herpes zoster is caused by Varicella - Zoster virus (VZV) , classically occurs unilaterally within the distribution of a sensory nerve, being characterized by clustered vesicles and considerable neuralgia
Pathogen and PathogenesisPathogen(VZV)Varicella-Zoster1SViruscharacterizedneurotropism andbydermatotropismHOUSE
Pathogen and Pathogenesis Pathogen Varicella-Zoster virus (VZV) is characterized by neurotropism and dermatotropism
PathogenesisVZVI the primary infectionnonimmune hostvaricellaVZV establishesganglialatencyinsensoryI the declinefunctioninimmuneVZVreplicate latermayHerpeszostershowingandclusteredvesiclesneuralgia
Pathogenesis VZV ↓ the primary infection nonimmune host ↓ varicella ↓ VZV establishes latency in sensory ganglia ↓ the decline in immune function VZV may replicate later ↓ Herpes zoster showing neuralgia and clustered vesicles
The incidence of herpeszosterwithandadvancingincreasesagedecline in immunefunctionOtherthanimmunosuppressionandinvolvedinage, the factorsunknownreactivationare
The incidence of herpes zoster increases with advancing age and decline in immune function. Other than immunosuppression and age, the factors involved in reactivation are unknown
Clinical manifestationsProdrome:feverheadache andhyperaesthesiapain in the affectedarea
Clinical manifestations Prodrome: ⚫ headache and fever ⚫ hyperaesthesia ⚫ pain in the affected area
Features of lesionsinitiallyas papules and plaquespresentsof erythemaredofclusteredpapules formcropsbanddiscontinuousainevolvevesiclesto clearsurroundedbyerythema
Features of lesions ⚫ initially presents as papules and plaques of erythema ⚫ crops of clustered red papules form in a discontinuous band ⚫ evolve to clear vesicles surrounded by erythema
theyhave feweruptionmaylesionsor reachtotal confluencein thedermatomebecomehemorrhagiclesionsmay bullousnecrotic, or
⚫ the eruption may have few lesions or reach total confluence in the dermatome ⚫ lesions may become hemorrhagic, necrotic, or bullous
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Herpes zoster