Chapter 12: Cardiovascular Physiology Regulation of Cardiovascular Activities Lecture Outline .Nervous Regulation .Humoral Regulation .Autoregulation
Chapter 12: Cardiovascular Physiology Regulation of Cardiovascular Activities Lecture Outline •Nervous Regulation •Humoral Regulation •Autoregulation
Nervous Regulation
Nervous Regulation
Innervation of cardiovascular system IX afferert Medullary X.afferent use cardiovascular centre Vagal motor Aortic baroreceptor Acetylcholine ■Vessel node musc Adrenaline in bloo Noradrenaline Acetylcholine transmitter Sympathetic stimulation increases contractility. frequency,conduction velocity,and irritability
Innervation of cardiovascular system
Nervous regulation of the circulation Heart Blood Vessel Vasoconstriction Intropy NE Vasoconstriction Chronotropy Vasodilation Dromotropy Sympathetic M Vasodilation /Nerve Terminal ACh Parasympathetic Sympathetic Cholinergic Nerve lerminal Nerve Terminal
Nervous regulation of the circulation
Cardiac mechanisms of norepinephrine Na L) NorEpi Beta-】 Receptor Stimulate Cyelic-AMP
Cardiac mechanisms of norepinephrine
Mechanisms of norepinephrine -increased Nat&Ca2+permeability ·lr↑，phase4 spontaneous depolarization'个， autorhythmicity ·Ca2+influx个，phase0 amplitude&velocity↑， conductivity↑ ·Ca2+influx↑，Ca2+release个，[Ca2+],↑，contractility↑
Mechanisms of norepinephrine —increased Na + & Ca2+ permeability • If ↑, phase 4 spontaneous depolarization ↑, autorhythmicity ↑ • Ca2+ influx ↑, phase 0 amplitude & velocity ↑, conductivity ↑ • Ca2+ influx ↑, Ca2+ release ↑, [Ca2+ ]i ↑, contractility ↑
Asymmetrical innervation of sympathetic nerve Time(min)
Asymmetrical innervation of sympathetic nerve
Cardiac mechanisms of acetylcholine Na(L) Ach NorEpl Beta-l Rec的t0 Receptor Stimulate's Cyelie-AMP
Cardiac mechanisms of acetylcholine
Mechanisms of acetylcholine -increased K+permeability ·K*outward↑，MRPI个，phase4 spontaneous depolarization↓，autorhythmicity Inhibition of Ca2+channel,phase 0 amplitude velocity,conductivity ·Ca2+influx↓，[Ca2+]↓，contractility↓
Mechanisms of acetylcholine —increased K + permeability • K + outward ↑, |MRP| ↑, phase 4 spontaneous depolarization ↓, autorhythmicity ↓ • Inhibition of Ca2+ channel, phase 0 amplitude & velocity ↓, conductivity ↓ • Ca2+ influx ↓, [Ca2+ ]i ↓, contractility ↓
明 Cardiac effect of parasympathetic stimulation Parasympathetic stimulation Before vagal stimulation During vagal stimulation 100 75 023 八N 人 0123 Time(s)
Cardiac effect of parasympathetic stimulation