Leland H. Hartwell / Michael L, Goldberg / Janice A. FischerLeroyHood/Charles F.AquadroGeneticsFromGenestoGenomesFifth EditionThe followingPPTsarebasedonGenetics(5thedition)ThisInternationalStudent Editionis foruseoutsidethe u.s.ATIONMCGRAW-HIL
1-1 Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display The following PPTs are based on Genetics (5th edition)
1 Genetics: The study of biological inform..Part IV How genes travel on chromosomes11 Theeukaryotic chromosomePart IBasic principles: How traits are12 Chromosomal rearrangements andtransmitted13Bacterialgenetics2 Mendel's principles of heredity14Organellargenetics3 Extensions to Mendel's laws4 The chromosome theory ofinheritancePart V How genes are regulated5Linkage,recombination,and themapping15GeneregulationinprokaryotesPart I What genes are and what they do16Gene regulation in eukaryotes6 DNA structure, replication, and recombin.Part VI Usinggenetics7Anatomy and function of a gene:Dissection17 Manipulating the8 Gene expression: Theflow of informationCsoteukar18 The genetic analysis of developmentPart IlI Analysis of genetic information19A The genetics ofcancer19B Systems biology and the future of medicine9A Digital analysis of genomes9B Genomes andproteomesPart Vil Beyond the individual gene and genome10A Analyzinggenomic information20 Variation and selection in populations10BYeastgenetics:An example21 Genetics of eomplex traits10C Applications of genetic engineering ...1-2
1-2 Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display 1 Genetics: The study of biological inform. 2 Mendel’s principles of heredity 3 Extensions to Mendel’s laws 4 The chromosome theory of inheritance 5 Linkage, recombination, and the mapping 6 DNA structure, replication, and recombin. 7 Anatomy and function of a gene: Dissection 8 Gene expression: The flow of information Part I Basic principles: How traits are transmitted Part II What genes are and what they do Part III Analysis of genetic information Part IV How genes travel on chromosomes Part V How genes are regulated Part VII Beyond the individual gene and genome 9A Digital analysis of genomes 9B Genomes and proteomes 10A Analyzing genomic information 10B Yeast genetics: An example 10C Applications of genetic engineering . 11 The eukaryotic chromosome 12 Chromosomal rearrangements and . 13 Bacterial genetics 14 Organellar genetics 15 Gene regulation in prokaryotes 16 Gene regulation in eukaryotes 20 Variation and selection in populations 21 Genetics of complex traits Part VI Using genetics 17 Manipulating the genomes of eukaryotes 18 The genetic analysis of development 19A The genetics of cancer 19B Systems biology and the future of medicine
Scores =Mid-term exam 40%(Chapters 1-10)5%Quiz5%HomeworkFinal exam50% (Chapters 11-20)
3 Scores = Mid-term exam 40% (Chapters 1-10) Quiz 5% Homework 5% Final exam 50% (Chapters 11-20)
Chapter 1Genetics: The Study of BiologicalInformation
4 Genetics: The Study of Biological Genetics: The Study of Biological Information Information Chapter 1
Sectionsto studyl.1DNA:Thefundamental information molecule of life1.2Proteins:Thefunctional molecules of life processes1.3 Molecular similarities of all life-forms1.4 The modular construction of genomes1.5 Modern genetic techniques1.6Human geneticsand society1-5
1-5 Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Sections to study Sections to study 1.1 DNA: The fundamental information molecule of life 1.1 DNA: The fundamental information molecule of life 1.2 Proteins: The functional molecules of life processes 1.2 Proteins: The functional molecules of life processes 1.3 Molecular similarities of all life 1.3 Molecular similarities of all life-forms 1.4 The modular construction of genomes 1.4 The modular construction of genomes 1.5 Modern genetic techniques 1.5 Modern genetic techniques 1.6 Human genetics and society 1.6 Human genetics and society
Genetics:The science of heredityOne biological discipline studying the rules governing thefrequency of appearance of alternative traits in differentgenerations.The study of biological information.How organisms store,replicate,and transmit biologicalinformation to the next generation?Howthey use it duringtheir lifetime?1-6
1-6 Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display The science of heredity . One biological discipline studying the rules governing the One biological discipline studying the rules governing the frequency of appearance of al frequency of appearance of alternative traits in different ternative traits in different generations. generations. The study of biological information . How organisms store, replicate, and transmit biological information to the next generation? How they use it during their lifetime? Genetics:
ThedevelopmentofgeneticsDNAshowntocarry genetic information.Watson-CrickmodelofDNAChromosometheoryofRecombinantDNAtechnologydeveloped.DNA cloninginheritanceproposed.ApplicationofMendel'sbeginsTransmissiongeneticsworkpublishedgenomics beginsevolved1860s1870s1880s1890s1900s1910s1920s1930s1940s1950s1960s1970s1980s1990s2000sMendel'sworkEraofmoleculargenetics.Genomicsbegins.rediscovered,correlatedGeneexpression,regulationHumanGenomeProjectwithchromosomebehaviorunderstoodinitiatedinmeiosis1-7
1-7 Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display The development of genetics
Theaims ofgeneticstudiesToidentifygenes.To learn how genes determine particular traits.To understand how genes work together to create a cell and anindividualorganism1-8
1-8 Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display To identify genes. To learn how genes determine particular traits. To understand how genes work together to create a cell and an individual organism. The aims of genetic studies:
Seven recurring themes in this course:1The biologicalinformation fundamental to life is encoded inDNA.2.Biological function emerges primarily from proteins3.All living forms are descended from a commonancestorandare closely related at the molecular level.4The modular construction of genomes has allowed rapidevolution ofbiological complexity.5.Genetic techniques permit dissection of biological complexity.6.Our focus is on human genetics and the application of geneticdiscoveries tohuman problems.1-9
1-9 Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Seven recurring themes in this course: 1. The biological information fundamental to life is encoded in The biological information fundamental to life is encoded in DNA. 2. Biological function emerges primarily from proteins. Biological function emerges primarily from proteins. 3. All living forms are descended from a common ancestor and All living forms are descended from a common ancestor and are closely related at the molecular level. are closely related at the molecular level. 4. The modular construction of genomes has allowed rapid The modular construction of genomes has allowed rapid evolution of biological complexity. evolution of biological complexity. 5. Genetic techniques permit dissection of biological complexity. Genetic techniques permit dissection of biological complexity. 6. Our focus is on human genetics and the application of genetic Our focus is on human genetics and the application of genetic discoveries to human problems. discoveries to human problems
1.1 DNA: The fundamental-Nucleotideinformation molecule of lifeThe biologicalinformationfundamentaltolifeis encoded inDNA (deoxyribonucleic acid)Four bases-G(guanine),A(adenine), T (thymine), and CPolymer(cytosine)inDNADeoxyribosesugarNitrogenous BasePhosphatePhosphodiesterbonds-Nucleotide
1-10 Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display 1.1 DNA: The fundamental 1.1 DNA: The fundamental information molecule of life information molecule of life The biological information The biological information fundamental to life is encoded in fundamental to life is encoded in DNA (deoxyribonucleic acid deoxyribonucleic acid). Four bases Four bases – G (guanine), (guanine), A (adenine), (adenine), T (thymine), and (thymine), and C (cytosine) in DNA. (cytosine) in DNA. Nitrogenous Base