Leukemia loushifeng
Leukemia loushifeng
Introduction ·Definition History 1827 Velpeal with his blood "like gruel 1845 Benett Edinburg,England. with "color and consistency of their blood"; Virchow Berlin,Germany introduced leukemia from Greek meaning "white blood
Introduction • Definition History 1827 Velpeal with his blood "like gruel 1845 Benett Edinburg, England. with "color and consistency of their blood"; Virchow Berlin,Germany introduced leukemia from Greek meaning "white blood
正常外周血 病人外周血
Introduction ·Definition Leukemia is a group of clonal malignant deseases developed form hematopoietic stem cell or progenitor cell. that lead to Suppression of normal hematopoiesis Infiltrations in outside of bonemarrow
Introduction • Definition Leukemia is a group of clonal malignant deseases developed form hematopoietic stem cell or progenitor cell. that lead to Suppression of normal hematopoiesis Infiltrations in outside of bonemarrow
Introduction ·Classification Acute Leukemia Acute lymphocytic Leukemia (ALL) Acute myelogenous Leukemia or Acute non- lymphocytic Leukemia (AML,ANLL) Chronic Leukemia Chronic Granulocytic Leukemia (CGL,CML) Chronic lymphocytic Leukemia (CLL) Leukemia uncommon in clinic
Introduction • Classification Acute Leukemia Acute lymphocytic Leukemia（ALL） Acute myelogenous Leukemia or Acute nonlymphocytic Leukemia（AML，ANLL） Chronic Leukemia Chronic Granulocytic Leukemia（CGL，CML） Chronic lymphocytic Leukemia（CLL） Leukemia uncommon in clinic
Introduction ·Incidence ·The total morbidity: 1.8 2.67/100 thousands 1.6 higher than the 1.4 1.2 chance to win a 1 0.8 lottery(1/400 0.6 0.4 thousands 0.2 AML ALL CLL 。男：女=1.8：1
Introduction • Incidence • The total morbidity : 2.67/100 thousands higher than the chance to win a lottery(1/400 thousands ) • 男：女=1.8：1 0 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 1.8 AML ALL CLL
Introduction ·Prognosis 100% BMT CHEMO 0 1 234 5 YEAR
Introduction • Prognosis 100% 0 1 2 3 4 5 YEAR BMT CHEMO
Introduction Etiology and Pathogenes Virus ATLV HTLV-I HTLV-II HTLV-III Chemical substance Bemzene poisoning lonizing radiation
• Etiology and Pathogenesis Virus ATLV HTLV-I HTLV-II HTLV-III Chemical substance Bemzene poisoning Ionizing radiation Introduction
Introduction ·Pathogenesis Normal Stem cell mutation Leukemic stem cell Progenitor cells Blast cell
Introduction • Pathogenesis Normal Stem cell Blast cell Leukemic stemcell mutation Progenitor cells
Introduction 1)those that confer a proliferative or and survival KIT FLT:3↑，NF-1↓ ● 2)those that impair hematopoietic differentiation and confer properties of self-renewal RUNX1-ETO,CBFB-SMMHC TEL- RONX1 fusions mutation
Introduction • 1)those that confer a proliferative or and survival KIT FLT3 ↑， NF-1 ↓ • 2) those that impair hematopoietic differentiation and confer properties of self-renewal RUNX1-ETO,CBFB-SMMHC ,TELRONX1 fusions mutation