SummaryPlasmodium,Toxoplasma,Trypanosoma,Entamoeba,Leishmania,GiardiaIntroductionMorphologyLife CyclePathologyDiagnosisEpidemiology,Treatment and Prevention
Summary Introduction Morphology Life Cycle Pathology Diagnosis Epidemiology, Treatment and Prevention Plasmodium, Toxoplasma, Trypanosoma, Entamoeba, Leishmania, Giardia
Malaria Parasites(Plasmodium)
Malaria Parasites (Plasmodium)
CharlesLouis AlphonseLaveranFrenchdoctorInstitute PasteurParis,France1845-1922The Nobel Prize inPhysiologyorMedicine1907:find the P.falciparum inpatient's blood in 1880"inrecognitionofhisworkonthe roleplayed by protozoa incausing diseases
Charles Louis Alphonse Laveran French doctor Institute Pasteur Paris, France 1845-1922 The Nobel Prize in Physiology or Medicine 1907: find the P.falciparum in patient’s blood in 1880. "in recognition of his work on the role played by protozoa in causing diseases
RonaldRossGreatBritainUniversity CollegeLiverpool,GreatBritain1857-1932The Nobel Prize in PhysiologyorMedicine 1902:findthevector(mosguito)andinfectionrouteofmalariain1897"forhis work on malaria,by whichhehasshownhowitenterstheorganismandtherebyhaslaidthefoundation for successful researchon thisdisease andmethods ofcombatingit
Ronald Ross Great Britain University College Liverpool, Great Britain 1857-1932 The Nobel Prize in Physiology or Medicine 1902: find the vector (mosquito) and infection route of malaria in 1897 "for his work on malaria, by which he has shown how it enters the organism and thereby has laid the foundation for successful research on this disease and methods of combating it
IntroductionFourspeciesinfectinghumans:P. vivax (Pv)P.falciparum (Pf)P.malariae (Pm)P.ovale (Po)
Introduction Four species infecting humans: P. vivax (Pv) P. falciparum (Pf) P. malariae (Pm) P. ovale (Po)
SpeciesHostGenomesBindsAvianPgallineceum1cladeAodentsP.chabaudiRodentPbergheicladeP.yoelHumens旦PvivexMonkeyRP.cymomolgiMonkey红旦cladeP.knowlasi国国PmalariaePovaleAricanapeMP.reichenowiHominidcladeAP.faiciparum20F
MosquitoSporozoiteSporozoite001010LiverOocyst08%MerozoiteErythrocytic stageOokineteZygoteErythrocyte0QOOOQGametocytesRedbloodcellsdOokineteOocyst0FemaleMerozoitesgametocytewallMidgutMalegametocyte
Anophelesgambiae:adultfemalebloodfeedingonhumanskin
Anopheles gambiae: adult female bloodfeeding on human skin
Characteristic of life cycleIntermediatehost:humanFinalhost:mosquitoInfectivestage:sporozoiteInfectivemode:mosquitobiteskinofhumanParasiticposition:liverandredbloodcells(symptomatic)Transmitted stage:gametocytesSchizogoniccycleinredcells:48hrs/Pv;36-48hrs/PfSporozoite:tachysporoziteandbradysporozite
Characteristic of life cycle Intermediate host : human Final host : mosquito Infective stage : sporozoite Infective mode : mosquito bite skin of human Parasitic position : liver and red blood cells (symptomatic) Transmitted stage : gametocytes Schizogonic cycle in red cells : 48 hrs/Pv；36-48 hrs/Pf Sporozoite : tachysporozite and bradysporozite
Life Cycle in Mosquito10daysat25Inmosquito stomach:gametogony:stomach lumengamogenesissexualreproductionsporogony:stomachwall agamogenesisasexualreproductionOokineteOocyst0FemalegametocyteOzygoteMidgutMalegametocyte
Life Cycle in Mosquito 10 days at 25℃ In mosquito stomach: gametogony: stomach lumen gamogenesis sexual reproduction sporogony: stomach wall agamogenesis asexual reproduction zygote