Leishmania
Leishmania
IntroductionLeishmaniasisProtozoal disease of mammalsLargely zoonoticVisceral LeishmaniasisMucocutaneous leishmaniasisCutaneous leishmaniasis
Introduction Leishmaniasis Protozoal disease of mammals Largely zoonotic Visceral Leishmaniasis Mucocutaneous leishmaniasis Cutaneous leishmaniasis
Species Pathogenic in HumansLeishmania donovanii (Laveran 1903) (VL)Leishmania tropica (CL)Leishmania major (CL)Leishmania aethiopica (CLLeishmania mexicana (CL)Leishmania brazilliensis (MCL)
Species Pathogenic in Humans Leishmania donovani (Laveran 1903) (VL) Leishmania tropica (CL) Leishmania major (CL) Leishmania aethiopica (CL) Leishmania mexicana (CL) Leishmania brazilliensis (MCL)
eographic distributionofVisceral LeishmaniasisLeishmaniasis is prevalent world wide: ranging fromsouth east Asia, Indo-Pakistan, Mediterranean, north andcentral Africa, and south and central America
Leishmaniasis is prevalent world wide: ranging from south east Asia, Indo-Pakistan, Mediterranean, north and central Africa, and south and central America
MorphologyNonflagellarstageoramastigote（无鞭毛体）Two stagesinlifecycleFlagella stage or promastigote（前鞭毛体）Nonflagellar stage in man and reservoir mammals.Flagella stageinthe sandfly andin cultures.Reproduction occurs by longitudinal binarydivision in both stages
Morphology
Morphology: Promasitgote. Amastigote- Insect- Mammalian stage- Motile- Non-motile- Midgut-Intracellular
Morphology • Promasitgote – Insect – Motile – Midgut • Amastigote – Mammalian stage – Non-motile – Intracellular
MorphologyThe individual amastigoteanteriormeasure approximately 3 μm inFlagellumdiameter. Leishman-Donvanbody.+abThe promastigotes arek1approximately 25 μum in lengthna. Rhizoplastkinetoplastb. Basal bodyk. Kinetoplastamastigotepromastigoten. nucleusposterior
Morphology • The individual amastigote measure approximately 3 µm in diameter. Leishman-Donvan body. • The promastigotes are approximately 25 µm in length. a. Rhizoplast b. Basal body k. Kinetoplast n. nucleus
Promastigote
Promastigote
Electron photomicrograph ofpromastigotes
Electron photomicrograph of promastigotes
EP promastigote rosette1806
EP promastigote rosette