
新技术新方法合成3.4-二氢嘧啶-2-酮王彦广
新技术新方法合成3,4-二氢嘧啶-2-酮 王彦广

嘧啶3,4-二氢嘧啶-2-酮pyrimidine3, 4-dihydro pyrimidine-2-ketones
3,4 -二氢嘧啶 - 2 - 酮 3, 4 -dihydro pyrimidine - 2 -ketone s 嘧啶 pyrimidine

嘧啶-2-酮3.4-二氢嘧啶-2-酮3, 4-dihydro pyrimidine-2-ketonespyrimidine-2-ketones
3,4 -二氢嘧啶 - 2 - 酮 3, 4 -dihydro pyrimidine - 2 -ketone s 嘧啶 - 2 - 酮 pyrimidine - 2 -ketones

3.4-二氢嘧啶-2-酮1,4-二氢嘧啶3, 4-dihydropyrimidine-2-ketones3,4-dihydropyrimidines
3,4 -二氢嘧啶 - 2 - 酮 3, 4 -dihydropyrimidine - 2 -ketones 1,4 -二氢嘧啶 3, 4 -dihydropyrimidines

102Xeloda(Capecitabine)尿嘧啶NHHOOHRoche$1079MillionAntimetabolites5-氟尿嘧啶5-fluoropyrimidin-2(1H)-one
5-氟尿嘧啶 5-fluoropyrimidin-2(1H)-one 尿嘧啶

Biginelli反应3,4-二氢嘧啶-2(1H)-酮Biginelli, P.Ber 1891,24, 1317; 2962Biginelli, P. Ber 1893, 26, 447
Biginelli反应 3,4-二氢嘧啶-2(1H)-酮 Biginelli, P. Ber. 1891, 24, 1317; 2962. Biginelli, P. Ber. 1893, 26, 447

各种β-酮酸酯、硫脉可参与Biginelli反应质子酸和Lewis酸均可催化Biginelli反应
各种β-酮酸酯、硫脲可参与Biginelli反应 质子酸和Lewis酸均可催化Biginelli反应

Biginelli反应的机理Kappe, C. O. J. Org. Chem. 1997, 62, 7201
Biginelli 反应的机理 Kappe, C. O. J. Org. Chem. 1997, 62, 7201

串联反应tandem reactions/cascade reactions多组分反应multicomponent reactions (MCRs)
串联反应 tandem reactions/cascade reactions 多组分反应 multicomponent reactions (MCRs)

Cascade/Domino/TandemReactions& Multi-componentReactions (MCRs) Aprocess involves two or more bond-forming transformations in asingle step.2multi-stepsingle-step
Cascade/Domino/Tandem Reactions & Multi-component Reactions (MCRs) A process involves two or more bond-forming transformations in a single step. multi-step single-step