Why Proteomics DNA mRNA is simpler to analyse than proteins, however Protein expression levels are not predictable from mRNA expression levels Proteins are uniquely modified and processed in ways which are not apparent from the Gene sequence Proteomes are dynamic and reflect the state of Biological Systems Post-Translational Modifications Gegereme mRNA Prptoeame Transcription Translation
Proteomics/ Proteome citations 1400 1200 1000 800 600 400 200 0 199219941996199820002002 Year published
最早于1994年由澳大利亚一位博士后 Wilkins提出,指的是“一个细胞或一个组 织基因组所表达的全部蛋白质。” 整体性、动态性和系统性
❖ 最早于1994年由澳大利亚一位博士后 Wilkins提出,指的是“一个细胞或一个组 织基因组所表达的全部蛋白质。 ” ❖ 整体性、动态性和系统性
protein-ligand interaction ion/small molecule nuclear pore complex protein complexes (machines) ribosomes transmembrane post-translationally modified proteins protein families membrane (activity or structural) Representation of a eukaryotic Cell
Representation of a eukaryotic Cell
定义:蛋白质组学( proteomics),就是从整体 的角度,分析细胞内动态变化的蛋白质组成成 份、表达水平与修饰状态,了解蛋白质之间的 相互作用与联系,揭示蛋白质功能与细胞生命 活动规律的一个新的研究领域
❖ 定义:蛋白质组学(proteomics),就是从整体 的角度,分析细胞内动态变化的蛋白质组成成 份、表达水平与修饰状态,了解蛋白质之间的 相互作用与联系,揭示蛋白质功能与细胞生命 活动规律的一个新的研究领域
of Genomics Proteomics Department of Genetics Biochemistry RXR actin ras BRCA Wnt Proteomics includes not only the identification and quantification of proteins, but also the determination of their localization, modifications, interactions, activities, and, ultimately, their function
Proteomics includes not only the identification and quantification of proteins, but also the determination of their localization, modifications, interactions, activities, and, ultimately, their function