Antituberculous drug First-line agents: Isoniazid(INH) Rifampin Pyrazinamide Ethambutol Streptomycin
Antituberculous drug First-line agents: Isoniazid(INH) Rifampin Pyrazinamide Ethambutol Streptomycin
Second-line agents Ofloxacin Ciprofloxacin Para-amino salicylic acid Amikacin
Second-line agents : Ofloxacin Ciprofloxacin Para-amino salicylic acid Amikacin
Isoniazid 【Antibacterial action】 1.Isoniazid has narrow antibacterial spectrum 2.It is active against mycobacterium tuberculosis 3.It is bacteriostatic in the stationary phase it is bactericidal in rapidly dividing organisms 3.It is able to penetrate into phagocytic cells
Isoniazid 【Antibacterial action】 1. Isoniazid has narrow antibacterial spectrum 2. It is active against mycobacterium tuberculosis 3. It is bacteriostatic in the stationary phase it is bactericidal in rapidly dividing organisms 3. It is able to penetrate into phagocytic cells
【Mechanism of action】 It inhibits the enzyme responsible for assembly of mycolic acids into the outer layer of the mycobacteria
It inhibits the enzyme responsible for assembly of mycolic acids into the outer layer of the mycobacteria, 【Mechanism of action】
Clinical uses】 It is used for treatment of latent tuberculosis. Usually it combined with other dugs was given to treat tuberculosis
【Clinical uses 】 It is used for treatment of latent tuberculosis. Usually it combined with other dugs was given to treat tuberculosis
【adverse effect】 1.Peripheral neuritis: hand-foot trembling,anesthesia 2.Hepatitis and idiosyncratic hepatotoxicity: fatal hepatitis 3.Other adverse effects: mental abnormalities,seizures optic neuritis Hypersensitivity reactions
【adverse effect 】 1. Peripheral neuritis: hand-foot trembling, anesthesia 2. Hepatitis and idiosyncratic hepatotoxicity: fatal hepatitis 3. Other adverse effects: mental abnormalities, seizures , optic neuritis , Hypersensitivity reactions
Rifampicin 1.Rifampin is bactericidal for both intracellular and extracellular mycobacteria 2.It is effective against many gram (+and gram (-)organisms 3.Rifampin is the most active anti-leprosy drug at present. 4.It blocks transcription by interacting with bacterial DNA-dependent RNA polymerase, thus inhibiting RNA synthesis
Rifampicin 1. Rifampin is bactericidal for both intracellular and extracellular mycobacteria 2. It is effective against many gram (+) and gram (-) organisms 3. Rifampin is the most active anti-leprosy drug at present. 4. It blocks transcription by interacting with bacterial DNA-dependent RNA polymerase, thus inhibiting RNA synthesis
【Clinical uses and Adverse effects】 1.Mycobacterial infections: rifampin is administered together with isoniazid, ethambutol,or another antituberculous drug 2.Serious staphylococcal infections: Rifampin combination therapy is use for treatment of serious staphylococcal infections 3.Rifampin causes nausea,vomiting,rash,and fever
【Clinical uses and Adverse effects 】 1. Mycobacterial infections: rifampin is administered together with isoniazid, ethambutol, or another antituberculous drug 2. Serious staphylococcal infections: Rifampin combination therapy is use for treatment of serious staphylococcal infections 3. Rifampin causes nausea, vomiting, rash, and fever
Antiviral drug and antifungal agent Section I Antiviral drug
Antiviral drug and antifungal agent Section I Antiviral drug
一、 Treatment of viral respiratory infections Amantadine Rimantadine Ribavirin
一、Treatment of viral respiratory infections Amantadine Rimantadine Ribavirin