有机化学 Organic chemistry 2010 For Undergraduates in biological science 王俊儒张继文袁茂森 应用化学系416,417室 87092187(0) By Junru Wang Email:wangjr07@163.com 西北农林科技大学理学院
Content Molecular Chirality Chiral carbon Absolute and Relative Configuration Stereoisomers without chiral carbons Properties of Enantiomers Diastereomers Resolution of Enantiomers
Key Notes Stereochemistry Chiral enantiomers Chirality Chiral center Optical rotations R/S,D/L Diastereomers meso forms Resolution of enantiomers
Stereoisomers Same bonding sequence. Different arrangement in space. Example:HOOC-CH=CH-COOH has two geometric(cis-trans)isomers: OH HO- OH HO-( fumaric acid,mp 287 C maleic acid,mp 138C essential metabolite toxic irritant
Sec 1 Chirality "Handedness":right glove doesn't fit the left hand. Mirror-image object is different from the original object. right hand left hand Prenice Hall,,lnc
Chirality A molecule is chiral if its two mirror image forms are not superposable upon one another. A molecule is achiral if its two mirror image forms are superposable