5. Powders and granules
5. Powders and Granules
Contents Powders l. Medicated powders l. Granules
Contents I. Powders II. Medicated powders III. Granules
I Powders a dry substance composed of finely divided particles A medicated powder intended for internal (i.e. oral powder) or external (i. e, topical powder)use
I. Powders ◼ A dry substance composed of finely divided particles ◼ A medicated powder intended for internal (i.e. oral powder) or external (i.e., topical powder) use
Powders are intimate mixtures of dry, finely divided drugs and lor chemicals that may be intended for internal or external use e.g. tablets, capsules, liquid dosage forms, ointments and creams
◼ Powders are intimate mixtures of dry, finely divided drugs and /or chemicals that may be intended for internal or external use. ◼ e.g. tablets, capsules, liquid dosage forms, ointments and creams
Granules are prepared agglomerates of powdered materials, may be used per se for the medicinal value of their content or they may be used for pharmaceutical purposes, as in making tablets
Granules are prepared agglomerates of powdered materials, may be used per se for the medicinal value of their content or they may be used for pharmaceutical purposes, as in making tablets
Before their use in the preparation of pharmaceutical products, solid materials first are characterized to determine their chemical and physical features including their morphology purity, solubility stability, particle sIze, a uniformity, compatibility with any other formulation components
Before their use in the preparation of pharmaceutical products, solid materials first are characterized to determine their chemical and physical features including their ◼ morphology, ◼ purity, ◼ solubility, ◼ stability, ◼ particle size, ◼ uniformity, ◼ compatibility with any other formulation components
Particle size and analysis Opening of standard sieves" Sieve nunber Sieve opening 9.5mm 234800o 5.6mm 4.75mm 2.36mm 200mm 26 850um 3 600Lm 40 425m 5O 300Lm 60 250m Zo 212以m sO 180,m 100 150,m 120 125Lm 200 75 Im 230 63 Hm 270 53 Im 325 45 Hm 400 38 Im Adapted from USP23-NFI8
一、Particle size and analysis
Powders of vegetable and animal drugs are officially defined as follows Very coarse(No 8): All particles pass through a No 8 sieve(2.36 mm) and not more than 20% through a No. 60 sieve (250m) Coarse(No 20): All particles pass through a No 20 sieve( 850 um)and not more than 40% through a No 60 sieve
Powders of vegetable and animal drugs are officially defined as follows: - Very coarse (No. 8): All particles pass through a No. 8 sieve (2.36 mm) and not more than 20% through a No. 60 sieve (250 m). - Coarse (No. 20): All particles pass through a No. 20 sieve (850 m) and not more than 40% through a No. 60 sieve
Moderately coarse(No 40 All particles pass through a No 40 sieve (425 um)and not more than 40% through a No 80 sieve(180 um) Fine(No. 60) All particles pass through a No 60 sieve (250 um) and not more than 40% through a No 100 sieve(150 um) Very fine(or a No. 80) I particles pass through a No 80 sieve There is no limit to greater fineness
- Moderately coarse (No. 40): All particles pass through a No. 40 sieve (425 m) and not more than 40% through a No.80 sieve (180 m). - Fine (No. 60): All particles pass through a No. 60 sieve (250 m) and not more than 40% through a No. 100 sieve (150 m). - Very fine (or a No. 80): All particles pass through a No. 80 sieve. There is no limit to greater fineness
The powder fineness for chemicals is defined as follows Course(or a No 20) powder-All particles pass through a No. 20 sieve and not more than 60% through a No. 40 sieve Moderately Course(or a No. 40) powder I particles pass through a No 40 sieve and not more than 60% through a No 60 sIeve
The powder fineness for chemicals is defined as follows ◼ Course (or a No. 20) powder-All particles pass through a No. 20 sieve and not more than 60% through a No. 40 sieve. ◼ Moderately Course (or a No. 40) powderAll particles pass through a No. 40 sieve and not more than 60% through a No. 60 sieve
