13. Disperse Systems (分散体系)
13. Disperse Systems (分散体系）
Contents Suspensions(混悬剂) Emulsions(乳剂) Gels and magmas(凝胶剂和乳浆剂) Proper administration and use of disperse systems(分散体系的正确给药和使用) Aerosols(气雾剂)
Contents ◼ Suspensions （混悬剂） ◼ Emulsions （乳剂） ◼ Gels and magmas （凝胶剂和乳浆剂） ◼ Proper administration and use of disperse systems （分散体系的正确给药和使用） ◼ Aerosols （气雾剂）
Liquid preparations containing undissolved or immiscible drug distributed throughout a vehicle In these preparations, the substance distributed is referred to as dispersed phase and the vehicle is termed the DDD dispersing phase or dispersion medium Together, they produce a dispersed system
◼ Liquid preparations containing undissolved or immiscible drug distributed throughout a vehicle. ◼ In these preparations, the substance distributed is referred to as dispersed phase, and the vehicle is termed the dispersing phase or dispersion medium. ◼ Together, they produce a dispersed system
The particles of the dispersed phase are vary widely in size. Dispersions containing coarse particles usually 10 to 50 um, are referred to as coarse dispersions, they include the suspensions and emulsions。 a Dispersions containing particles of smaller size are termed fine dispersions(0.5-10um). a If the particles are in the colloidal range, colloidal dispersions a Magmas and gels are fine dispersions
The particles of the dispersed phase are vary widely in size. ◼ Dispersions containing coarse particles, usually 10 to 50 m, are referred to as coarse dispersions; they include the suspensions and emulsions. ◼ Dispersions containing particles of smaller size are termed fine dispersions (0.5~10m). ◼ If the particles are in the colloidal range, colloidal dispersions. ◼ Magmas and gels are fine dispersions
Suspensions Suspensions may be defined as preparations containing finely divided drug particles distributed somewhat uniformly throughout a vehicle in which the drug exhibits a s minimum degree of solubility 混悬剂系指难溶性固体药物以微粒状态分 散于分散介质中形成的多相分散体系
Suspensions ◼ Suspensions may be defined as preparations containing finely divided drug particles distributed somewhat uniformly throughout a vehicle in which the drug exhibits a minimum degree of solubility. ◼ 混悬剂系指难溶性固体药物以微粒状态分 散于分散介质中形成的多相分散体系
Some suspensions are available in ready-to-use form, that is, already distributed through a liquid vehicle with or without stabilizers and other additives.(一些混悬剂在有或无稳定剂和其他药 用添加剂的情况下分散在液体介子中而供使用)
Some suspensions are available in ready-to-use form, that is, already distributed through a liquid vehicle with or without stabilizers and other additives. （一些混悬剂在有或无稳定剂和其他药 用添加剂的情况下分散在液体介子中而供使用）
Other preparations are available as dry powders intended for suspension in liquid vehicles.(其他制剂还有分散到液体介质中 能形成混悬剂的干粉)。 mixture containing the drug and suitable w a This type of product generally is a powde suspending and dispersing agents to be diluted and agitated with a specified quantity of vehicle, generally purified water
◼ Other preparations are available as dry powders intended for suspension in liquid vehicles. （其他制剂还有分散到液体介质中 能形成混悬剂的干粉）。 ◼ This type of product generally is a powder mixture containing the drug and suitable suspending and dispersing agents to be diluted and agitated with a specified quantity of vehicle, generally purified water
Megace ES Megestrol acetate oral suspension Dose 625mq 800 Volume 5 mL (teaspoon) 20 mL(dosing cup) Bioequivalent in fed condition Bioequivalent in fed condition Dosing with regard to food! 4 in unfed condition reduced in unfed condition Dispensed as 30-day (1 month)bottle 12- or 24-day bottles 醋酸甲地孕酮口服混悬剂
醋酸甲地孕酮口服混悬剂
Reasons for Suspensions There are several reasons for preparing suspensions 1) The suspension ensures chemical stability while permitting liquid therapy..(混悬剂以 液体形式给药保证了药物的化学稳定性。)
Reasons for Suspensions There are several reasons for preparing suspensions. 1）The suspension ensures chemical stability while permitting liquid therapy.（混悬剂以 液体形式给药保证了药物的化学稳定性。）
2) For many patients, the liquid form is because of the ease of swallowing liquid preferred to the solid form of the same drug and the flexibility in administration of a range of doses (对许多病人来说,服用同一种药物的液 体制剂比固体制剂更容易接受,这是因为 液体便于吞服并能在一定范围内很方便的 改变给药剂量)
2）For many patients, the liquid form is preferred to the solid form of the same drug because of the ease of swallowing liquids and the flexibility in administration of a range of doses. （对许多病人来说，服用同一种药物的液 体制剂比固体制剂更容易接受，这是因为 液体便于吞服并能在一定范围内很方便的 改变给药剂量）