Novel Dosage Forms And Drug Delivery Technologies
Novel Dosage Forms And Drug Delivery Technologies
Main Contents 1 Introduction 2. Topical Administration 3. Oral Administration 4. Vaginal Administration 5. Ophthalmics 6. Parenteral Administration 7. Peglated Dosage Forms 8.Fusion Protein 9.Implants 10.Other Novel Delivery Systems
2 Main Contents • 1. Introduction • 2.Topical Administration • 3.Oral Administration • 4.Vaginal Administration • 5.Ophthalmics • 6.Parenteral Administration • 7.Peglated Dosage Forms • 8.Fusion Protein • 9.Implants • 10.Other Novel Delivery Systems
Introduction This chapter discusses novel drug delivery systems that are modifications of those previously presented, are relatively new on the market or do not fit into categories in previous chapters They may be relatively new, use new or relativel new delivery systems, or use unique delivery systems or unique devices before, during, or after administration
3 Introduction • This chapter discusses novel drug delivery systems that are modifications of those previously presented, are relatively new on the market, or do not fit into categories in previous chapters. • They may be relatively new, use new or relativel new delivery systems, or use unique delivery systems or unique devices before, during, or after administration
Introduction Changes are coming about as new technologies are developed and reduce the limitations of existing therapies In some cases, the new drugs require new delivery systems because the traditional systems are inefficient or ineffective this may be true especially of some of the recombinant dna and gene therapies of the future
4 Introduction • Changes are coming about as new technologies are developed and reduce the limitations of existing therapies. • In some cases, the new drugs require new delivery systems because the traditional systems are inefficient or ineffective; this may be true especially of some of the recombinant DNA and gene therapies of the future
Benefits: A)improvement of patients compliance; B)improved outcomes c reduction of adverse effects; D)improvement of patients' acceptance of the treatment E)avoidance of costly interventions such as laboratory services; F) allowing patients to receive medication as outpatients Ga reduction in the overall use of medicinal resources 5
5 Benefits: • A) improvement of patients’ compliance; • B) improved outcomes; • C) reduction of adverse effects; • D) improvement of patients’ acceptance of the treatment; • E) avoidance of costly interventions such as laboratory services; • F) allowing patients to receive medication as outpatients • G) a reduction in the overall use of medicinal resources
Therapeutic benefits Optimization of the duration of action of the drug ecreasing dosage trequency Controlling the site of release Maintaining constant drug level
6 Therapeutic benefits • Optimization of the duration of action of the drug; • Decreasing dosage frequency, • Controlling the site of release, • Maintaining constant drug level
Safety benefits Reducing adverse affects Decreasing the number of concomitant medications patient must take Decreasing the need for interventions Reducing the number of emergency department visits
7 Safety benefits • Reducing adverse affects, • Decreasing the number of concomitant medications patient must take, • Decreasing the need for interventions • Reducing the number of emergency department visits
Economic benefits Simplifying administration regiments: Enhancing patients' compliance An overall reduction of health care costs Solute(Drug) Cell Membrane A头 Adhesion Fusion Endocytosis
8 Economic benefits • Simplifying administration regiments; • Enhancing patients’ compliance • An overall reduction of health care costs
Introduction The therapeutic efficacy of selected products can be enhanced and in some cases the toxicity can be decreased by incorporating nove drug delivery technologies
9 Introduction • The therapeutic efficacy of selected products can be enhanced and in some cases the toxicity can be decreased by incorporating novel drug delivery technologies
Introduction With these novel dosage forms and drug delivery technologies, some therapies may become very site specific; and more controlled drug delivery systems will be available in the very near future 10
10 Introduction • With these novel dosage forms and drug delivery technologies, some therapies may become very site specific; and more controlled drug delivery systems will be available in the very near future
