11ChapterofDiseasesurinarysystem
Chapter 11 Diseases of urinary system
Int roduction
Functions of kidney(一)1.Excretes the wasteproducts of metabolism2. Precisely regulates the body'sconcentration ofwaterand salt3.Maintains the appropriate acid-alkalinebalanceofplasma4.Serves as an endocrine organ:erythropoietinreninprostaglandin
(一) Functions of kidney 1. Excretes the waste products of metabolism 2. Precisely regulates the body’s concentration of water and salt 3. Maintainsthe appropriate acidalkaline balance of plasma 4. Serves as an endocrine organ: erythropoietin renin prostaglandin
(二) RenalstructureCapillary tuftGlomerulusRenal capsule(Bowman's capsule)NephronProximal tubuleThin segmentRenal tubuleDistal tubuleCollecting duct
(二) Renal structure Nephron Collecting duct Glomerulus Renal tubule Capillary tuft Renal capsule (Bowman’s capsule) Proximal tubule Thin segment Distal tubule
Renalstructure△proximal tubuledistal tubule△
Renal structure proximal tubule distal tubule
GLOMERULUSCapillaryUrinaryspaceloopsMesangiumMesangial cellMesangial matrixRed cellParietal epitheliumFenestrae inProximalendotheliumtubuleUrinary spaceCapillarylumenParietalepitheliumBasementmembraneVisceralepitheliumFootprocessesEndotheliumBasementmembraneRed cellBFootprocesses
Renalstructure
Renal structure
RenalstructureCLCI
Renal structure
1. Filteringmembrane· Endothelial cells (EC). Glomerular basement(GBM)membrane Visceral epithelial cell(podocyte）
1. Filtering membrane • Endothelial cells (EC) • Glomerular basement membrane (GBM) • Visceral epithelial cell ( podocyte )
FilteringmembraneRCaEpREp
Filtering membrane