Chapter 15Infectiousdisease
Infectious disease Chapter 15
S1IntroductionAlthough the features ofpathologic change of infectiousdiseases is different, its basicpathological changes is thesame, belong to the inflammation
§1 Introduction Although the features of pathologic change of infectious diseases is different, its basic pathological changes is the same, belong to the inflammation
InfectionInfluenzaDiphtheriaShigella dysenterySkin,throat,Ascendingpyelonephritislung,intestine,urinarytractLymphnodeDengueMalariaLymphaticTyphusBloodstreamBrainLiverSalivaryglandLungsKidneySkinPoliomyelitisHepatitisBYellowfeverMumpsRabiesChickenpoxHematogenousMeaslesYawspyelonephritisRubella
Acute:Fibrinous→bacillary dysentery;Suppurative-→suppurativemeningitisChronic:Granulomatouss inflammationTB,leprosy
◆ Acute: Fibrinous→bacillary dysentery; Suppurative→suppurative meningitis ◆ Chronic: Granulomatous inflammation TB, leprosy
S2Tuberculosis(一)Outline1. Concept:TB is a chronic granulomatousdisease caused by tubercle bacilliThe lung is his prime target, but anyorgan may be infected
§2 Tuberculosis (一) Outline 1. Concept: TB is a chronic granulomatous disease caused by tubercle bacilli The lung is his prime target, but any organ may be infected
The characteristic lesion Formation of tubercleCentral caseous necrosis
The characteristic lesion : ▪ Formation of tubercle ▪ Central caseous necrosis
2. ClassificationTBPulmonaryprimary TBsecondaryTBExtra pulmonary TBCintestinal TBtuberculous meningitistuberculous peritonitisTB of bone,jointTB ofLNTB ofurinary SgenitalS
2. Classification Pulmonary TB primary TB secondary TB Extra pulmonary TB intestinal TB tuberculous meningitis tuberculous peritonitis TB of bone , joint TB of LN TB of urinary S genital S
二. Etiology and Pathogenesis1. The pathogenic organismG+Mycobacterium TBTuberclebacillus(1) Type:M. hominidmainlyresponsibleforM.bovinedisease in manMouse, fish type-→have no virulence in host
二. Etiology and Pathogenesis 1. The pathogenic organism Mycobacterium TB G+ Tubercle bacillus (1) Type: M. hominid M. bovine Mouse, fish type→have no virulence in host mainly responsible for disease in man
Routesofinfection(2) Respiratory tract: maindirect personntopersontransmission of sneeze,cough droplets withorganisms(1-20 bacteria droplet)
(2) Routes of infection ① Respiratory tract: main direct person to person transmission of sneeze, cough droplets with organisms(1-20 bacteria / droplet)