Phenomenological Analysis of Drug Transport through Stratum Corneum Wang Hong
Phenomenological Analysis of Drug Transport through Stratum Corneum Wang Hong
Purpose o To illustrates the phenomenological relationship of drug permeable process through SC and provides theory and method for research of transdermal drug delivery(TDD)
Purpose ⚫ To illustrates the phenomenological relationship of drug permeable process through SC and provides theory and method for research of transdermal drug delivery (TDD)
Results (1)Not only drug transdermal permeation,but also volume loss of solution occurs in the system ● (2)According to experimental data,phenomenological coefficient is time variable,the action of surface force on mass flow and physical force on physical flow decreases as time expands (3)Volume flow may be generated by velocity gradient arising from solution convection on the surface of stratum corneum(SC)
Results ⚫ (1) Not only drug transdermal permeation, but also volume loss of solution occurs in the system ⚫ (2) According to experimental data, phenomenological coefficient is time variable, the action of surface force on mass flow and physical force on physical flow decreases as time expands ⚫ (3) Volume flow may be generated by velocity gradient arising from solution convection on the surface of stratum corneum (SC)
Conclusion The permeation chamber is a non-linear and time-variable system
Conclusion ⚫ The permeation chamber is a non-linear and time-variable system
INTRODUCTION ● advances in biotechnology A lot of therapeutic macromolecules are reaching the clinical application bioactive macromolecules limited A novel delivery system needed Transdermal drug delivery (TDD)
INTRODUCTION ⚫ advances in biotechnology ⚫ A lot of therapeutic macromolecules are reaching the clinical application ⚫ bioactive macromolecules limited ⚫ A novel delivery system needed ⚫ Transdermal drug delivery (TDD)
TDD(Transdermal drug delivery) TDD is that patching the drug on the skin,the drug molecules permeate through the skin into the subcutaneous capillary vessels ● TDD is an alternative method of drug delivery that draws people's attention as a potential administration of biological pharmacy
TDD (Transdermal drug delivery) ⚫ TDD is that patching the drug on the skin, the drug molecules permeate through the skin into the subcutaneous capillary vessels ⚫ TDD is an alternative method of drug delivery that draws people’s attention as a potential administration of biological pharmacy
Exist diffculty very few drugs can be administered transdermally at therapeutic levels to the barrier of stratum corneum (SC),the skin's outer layer
Exist diffculty ⚫ very few drugs can be administered transdermally at therapeutic levels to the barrier of stratum corneum (SC), the skin’s outer layer
Method to enhance iontophoresis electroporation o photomechanical wave sonophoresis magnetophoresis ●chemical enhancers
Method to enhance ⚫ iontophoresis ⚫ electroporation ⚫ photomechanical wave ⚫ sonophoresis ⚫ magnetophoresis ⚫ chemical enhancers
Non-equilibrium theory of permeation cell System of permeation cell and its hypothesis Permeation cell Phenomenological equation of permeation cell
Non-equilibrium theory of permeation cell ⚫ System of permeation cell and its hypothesis Permeation cell ⚫ Phenomenological equation of permeation cell
System of permeation cell Permeation cell,the basic equipment of TDD experiment in vitro is composed of a donor compartment and a receptor compartment, among which SC sample is loaded and a couple of electrodes were put at their sides The solution in donor is saturated liquid containing solute,while the solution in receptor is physiological saline
System of permeation cell ⚫ Permeation cell, the basic equipment of TDD experiment in vitro is composed of a donor compartment and a receptor compartment, among which SC sample is loaded and a couple of electrodes were put at their sides ⚫ The solution in donor is saturated liquid containing solute, while the solution in receptor is physiological saline