同济大学国际医学院制 Chapter 1:Cell structure Teacher's Name:Yi Sun Objectives Teaching (1)grasp the structural and functional characteristics of cell membrane. Objectives, (2)learn the basic concept of cell surface and its specified structures Teaching (3)grasp the basic concepts of organelles,endomembrane system and Requirements cytoskeleton: (6)understand the principle of ordinary optical microscope, (7)learn the basic structure system of eukaryotes; Requirements:Computer,Projector,laser pointer,microphone. (1)Chemical comp ents of cell membrane.structure model,and its structural andftnctionalcharactersticy Teaching (2)Basic concepts of cell surface and its specified structures Content (3)Basic concepts oforganelles,endomembrane system and cytoskeleton. (4)Structure,components and functional characteristics of nucleus. (5)Basic reasons for cell division and its controlling factors 6)Observation of basic of microscope and its orking principles Teaching Foci: Focus: (1)Chemical components of cell membrane,structure model,and its structural Difficult and functional characteristics Problems and (2)Basic concepts of cell surface and its specified structures Their Solutions ()Basic concepts of organelles.endomer rane system and cytoskeleton (4)Structure,components and functional characteristics of nucleus; Difficult points: (1)The basic structure system of eukaryotes: (2)Reasons for cell division and factors (4)New cognition of cell concept. Time Allotment
同济大学国际医学院制 Chapter 1：Cell structure Teacher's Name: Yi Sun Teaching Objectives; Teaching Requirements Objectives: (1) grasp the structural and functional characteristics of cell membrane; (2) learn the basic concept of cell surface and its specified structures (3) grasp the basic concepts of organelles, endomembrane system and cytoskeleton; (4) grasp the structure, components and functional characteristics of nucleus; (5) understand factors controlling cell division; (6) understand the principle of ordinary optical microscope; (7) learn the basic structure system of eukaryotes; Requirements: Computer, Projector, laser pointer, microphone. Teaching Content (1) Chemical components of cell membrane, structure model, and its structural and functional characteristics; (2) Basic concepts of cell surface and its specified structures; (3) Basic concepts oforganelles, endomembrane system and cytoskeleton; (4) Structure, components and functional characteristics of nucleus; (5) Basic reasons for cell division and its controlling factors (6) Observation of basic structure of microscope and its working principles Teaching Focus; Difficult Problems and Their Solutions Foci: (1) Chemical components of cell membrane, structure model, and its structural and functional characteristics; (2) Basic concepts of cell surface and its specified structures; (3) Basic concepts of organelles, endomembrane system and cytoskeleton; (4) Structure, components and functional characteristics of nucleus; Difficult points: (1) The basic structure system of eukaryotes; (2)Reasons for cell division and its controlling factors; (3) The principle of ordinary optical microscope; (4) New cognition of cell concept. Time Allotment
(1)Talk about the components of cell surface and their respective significance. Assignment/ (2)Talk about your own cognition about basic structure system of eukaryoti Thinking Questions (3)Why can a cell divide into two?What are the limiting factors? (4)Talk about your own cognition of cell concept. Postscript Memo Chapter 2:Cell membrane and cell junction Teacher's Name:Fu-Rong Gao After the class,the students should be able to: 1Understand the chemical composition and characteristics of membranes Objectives, Grasp the types of membrane transport and their differenes Teaching 3)Grasp the types of cell junction and their function Requirements 4)Know the adhesion molecules and extracellular matrix Requirements:Computer,Projector,laser pointer,microphone. 1)The chemical composition of membranes Teaching 3)Passive transport and active transport Content 4)Cell junction,adhesion molecules and extracellular matrix Teaching Focus Focus 1)Chemical composition and characteristics of membranes Passive ranspor and active transpor Problems and 3) Types of cell junction and their function Their Solutions 1)The chemical composition of membranes(20 min) 2)Characteristics of biomembrane(5min) Time Allotment 3)Passive transport and active transport(40 min) 1)What are the three main types of lipid molecules found in biomembranes Assignment/ 2)How are the three types similar and how are they different Thinking 3)How does active transport differ from facilitated diffusion? Questions 4)What is the function of a gap junction?
Assignment/ Thinking Questions (1)Talk about the components of cell surface and their respective significance. (2) Talk about your own cognition about basic structure system of eukaryotic cell. (3) Why can a cell divide into two? What are the limiting factors? (4) Talk about your own cognition of cell concept. Postscript Memo Chapter 2：Cell membrane and cell junction Teacher's Name: Fu-Rong Gao Teaching Objectives; Teaching Requirements After the class, the students should be able to: 1) Understand the chemical composition and characteristics of membranes 2) Grasp the types of membrane transport and their differences 3) Grasp the types of cell junction and their function 4) Know the adhesion molecules and extracellular matrix Requirements: Computer, Projector, laser pointer, microphone. Teaching Content 1) The chemical composition of membranes 2) Characteristics of biomembrane 3) Passive transport and active transport 4) Cell junction, adhesion molecules and extracellular matrix Teaching Focus; Difficult Problems and Their Solutions Focus: 1) Chemical composition and characteristics of membranes 2) Passive transport and active transport 3) Types of cell junction and their function Time Allotment 1) The chemical composition of membranes (20 min) 2) Characteristics of biomembrane (5min) 3) Passive transport and active transport (40 min) 4) Cell junction, adhesion molecules and extracellular matrix (25 min) Assignment/ Thinking Questions 1) What are the three main types of lipid molecules found in biomembranes? 2) How are the three types similar and how are they different? 3) How does active transport differ from facilitated diffusion? 4) What is the function of a gap junction?
Memo Chapter 3:Intracellular compartments Teacher's Name:Jing-Ying Xu and protein sorting After the class,the students should be able to: Teaching 1)Grasp the pathways of proteins targeting and sorting,and its mechanisms Objectives Know the ations and intracellular sites after the Teaching Requirements 3)Understand types of vesicle transport and their functions 4)Know endocytosis and phagocytosis Requirements:Computer.Proiector.laser pointer.microphone The pathways of proteins targetingand it s me The ways of protein modifications and intracellular sites after they are Teaching synthesized: Content 3)Types of vesicle transport and their functions; 4)Endocytosis and Phagocytosis:cellular uptake of macromolecules and Teaching Focus: Focus; 1)The pathways of proteins targeting and sorting,and its mechanisms Difficult 2)Types of vesicle transport and their functions Problems and Their Solutions The pathways of proteins targeting and sorting.and its mechanisms:(40 min) Time Allotment 2) The ways of protein modifications and intracellular sites after they are synthesized,(10min) 3)Types of vesicle transport and their functions.(30 min) Endocytosis and Phagocytosis particles.(10min)
Postscript Memo Chapter 3：Intracellular compartments Teacher's Name: Jing-Ying Xu and protein sorting Teaching Objectives; Teaching Requirements After the class, the students should be able to: 1) Grasp the pathways of proteins targeting and sorting, and its mechanisms 2) Know the ways of protein modifications and intracellular sites after they are synthesized 3) Understand types of vesicle transport and their functions 4) Know endocytosis and phagocytosis Requirements: Computer, Projector, laser pointer, microphone. Teaching Content 1) The pathways of proteins targeting and sorting, and its mechanisms; 2) The ways of protein modifications and intracellular sites after they are synthesized; 3) Types of vesicle transport and their functions; 4) Endocytosis and Phagocytosis: cellular uptake of macromolecules and particles. Teaching Focus; Difficult Problems and Their Solutions Focus: 1) The pathways of proteins targeting and sorting, and its mechanisms 2) Types of vesicle transport and their functions Time Allotment 1) The pathways of proteins targeting and sorting, and its mechanisms; (40 min) 2) The ways of protein modifications and intracellular sites after they are synthesized; (10 min) 3) Types of vesicle transport and their functions. （30 min） 4) Endocytosis and Phagocytosis: cellular uptake of macromolecules and particles. (10 min)
1)How proteins synthesized at the ribosomes are transported to various Assignment/ Thinking 2) sspecifically select cargo molecules? Questions 3)How is the cholesterol taken by cells? 4)What is autophage? Postscript Memo Chapter 4:Energy conversion:mitochondria Teacher's Name:Fu-Rong Gao After the class,the students should be able to: Teaching Grasp the relationship between the structure and function of Objectives; Know the principle of oxidative phosphorylation Teaching 3)Know the origins of mitochondria Requirements 4)Understand the relationship between mitochondria and diseases Requirements:Computer,Projector,laser pointer,microphone. Shapeand structure of 2) Electron transfer and oxidative phosphorylation Teaching 3)Origins of mitochondria Content 4)mitochondria and diseases Teaching Focus: Focus relationship bet ween the structure and function of mitochondria Problems and Their Solutions 1)Shape and structure of mitochondria(20 min) 2)Electron transfer and oxidative phosphorylation(35 min) Time Allotment3)Origins of mitochondria (15 min) 4) ochondria and diseases(20min)
Assignment/ Thinking Questions 1) How proteins synthesized at the ribosomes are transported to various organelles? 2) How do the clathrin-coated vesicles specifically select cargo molecules? 3) How is the cholesterol taken by cells? 4) What is autophage? Postscript Memo Chapter 4：Energy conversion: mitochondria Teacher's Name: Fu-Rong Gao Teaching Objectives; Teaching Requirements After the class, the students should be able to: 1) Grasp the relationship between the structure and function of mitochondria. 2) Know the principle of oxidative phosphorylation 3) Know the origins of mitochondria 4) Understand the relationship between mitochondria and diseases Requirements: Computer, Projector, laser pointer, microphone. Teaching Content 1) Shape and structure of mitochondria 2) Electron transfer and oxidative phosphorylation 3) Origins of mitochondria 4) mitochondria and diseases Teaching Focus; Difficult Problems and Their Solutions Focus: the relationship between the structure and function of mitochondria Time Allotment 1) Shape and structure of mitochondria (20 min) 2) Electron transfer and oxidative phosphorylation (35 min) 3) Origins of mitochondria (15 min) 4) mitochondria and diseases (20 min)
1)Please describe the structure of mitochondria Assignment Thinking permeable to chloride ions,what effect might this haveon the Questions proton-motive force across the inner mitochondrial membrane? Postscript Memo Chapter 5:Cytoskeleton Teacher's Name:Ying-Yu Cui Objectives: Teaching (1)grasp the concept of cytoskeleton and its main components: Obiectives (2)learn the relationship of cytoskeletal structures and their functions Teaching Requirements Requirements:Computer,Projector,laser pointer,microphone (1)microtubules (2)microfilaments Teaching (3)intermediate filaments Content (4)structure and function of cytoskeleton (5)cytoskeleton and diseases Teaching Foci Focus, (1)concept of eytoskeleton and its main components Difficult (2)relationship of cytoskeletal structure and function Problems and Difficult points: Their Solutions (1)polarity of microtubules and microfilaments and their dynamic assembling (2)small molecular inhbitors to cytoskeleton and their action mechanism Time Allotment
Assignment/ Thinking Questions 1) Please describe the structure of mitochondria. 2) If it were determined that the inner mitochondrial membrane was freely permeable to chloride ions, what effect might this have on the proton-motive force across the inner mitochondrial membrane? Postscript Memo Chapter 5：Cytoskeleton Teacher's Name: Ying-Yu Cui Teaching Objectives; Teaching Requirements Objectives: (1) grasp the concept of cytoskeleton and its main components; (2) learn the relationship of cytoskeletal structures and their functions (3) learn of the relationship of cytoskeleton and some diseases Requirements: Computer, Projector, laser pointer, microphone Teaching Content (1) microtubules (2) microfilaments (3) intermediate filaments (4) structure and function of cytoskeleton (5) cytoskeleton and diseases Teaching Focus; Difficult Problems and Their Solutions Foci: (1) concept of cytoskeleton and its main components (2) relationship of cytoskeletal structure and function Difficult points: (1) polarity of microtubules and microfilaments and their dynamic assembling (2) small molecular inhibitors to cytoskeleton and their action mechanism Time Allotment
(1Compare the similarity and difference between MT.MF and IF Assignment/ (2)How to certify the function of MT and MF to sustain cell shape Thinking (3)How to demarcate the positio of MTOC(microtubule organizing enter) Questions (4)Analyze the significance of IF in identifying the origin of tumor cells Postscript Memo Chapter 6:DNA,chromosomes and genomes Teacher's Name:Shane Gao 1.Introduce DNA and their role in cell biology Teaching Make students clear about the above concepts Obiectives: Guide the students to understand the DNA packaging.chromatin formation Teaching and hromosome behavior during Requirements Lead the students to think about of DNAand Requirements:Computer,Projector,laser pointer,microphone 1.The structure and function of DNA Teaching Chromosme DNA and its packaging in the chromatinfiber The regulation of chromatin stru Content 4. The global structure of chromosom Teaching How does the nucleolus can hold so long DNA strand? Focus: 2.How is the DNA packaged? Difficult 3.How does chromatin behave during cell cycling? Problems and Their Introduction nucleolus,chromatin and cell eycle (5min) Principles (10min) Time Allotment 3. Comparison of DNA.chromatin and chromosome (10 min) 4.Cell cycling mechanism and cell chromatin behavior (10min) 5.Link between cell cycling and chromosome bahaviors (20 min) 6 Regulation of chromatin structure,global structure of chromosome(20min)
Assignment/ Thinking Questions (1) Compare the similarity and difference between MT, MF and IF (2) How to certify the function of MT and MF to sustain cell shape (3) How to demarcate the position of MTOC( microtubule organizing center) (4) Analyze the significance of IF in identifying the origin of tumor cells Postscript Memo Chapter 6：DNA, chromosomes and genomes Teacher's Name: Shane Gao Teaching Objectives; Teaching Requirements 1. Introduce DNA and their role in cell biology Make students clear about the above concepts 2. Guide the students to understand the DNA packaging, chromatin formation and chromosome behavior during cell cycle. 3. Lead the students to think about the evolution role of DNA and nucleolus Requirements: Computer, Projector, laser pointer, microphone Teaching Content 1. The structure and function of DNA 2. Chromosome DNA and its packaging in the chromatin fiber 3. The regulation of chromatin structure 4. The global structure of chromosome Teaching Focus; Difficult Problems and Their Solutions 1. How does the nucleolus can hold so long DNA strand? 2. How is the DNA packaged? 3. How does chromatin behave during cell cycling? Time Allotment 1. Introduction nucleolus, chromatin and cell cycle (5min) 2. Principles (10min) 3. Comparison of DNA, chromatin and chromosome (10 min) 4. Cell cycling mechanism and cell chromatin behavior ( 10min) 5. Link between cell cycling and chromosome bahaviors (20 min) 6. Regulation of chromatin structure, global structure of chromosome (20 min )
7.Knowledge recalling and Assignment (15min) Total9 min Thinking Questions Assignment/ 1.What is chromatin and what is chromosome? Thinking 2.What is the relationship between chromatin behavior and cell cycling Questions 3 How to understand DNA packaging and mechanism 1. When explain DNA and their packaging pattern,using some economic thought Postscript Make student get easy to understand cell cyeling and chromatin behaviors Memo Chapter 7:Cell cycle and its regulation Teacher's Name:Ying-Yu Cui Teaching (1)grasp the concept of cell cycle and its main phases; Objectives, (2)grasp of the similarity and difference between mitosis and meiosis Teaching (3)leam of the regulatory mechanism of cell division and its relation with some Requirements diseases'occurrence Requirements:Computer,Projector,laser pointer,microphone (1)overview of cell cycle (2)regulation of cell cycle Teaching (3)cell division:mitosis vs meiosis Content (4)cell cycle and medicine (5)cell division and diseases Teaching Foci: Focus; (1)concept of cell cycle,checkpoints and the characteristics of each phase Difficult (2)Cyclins.CDK.CDKL PMF and their roles in cell cycle regulation Problems and Difficult points: Their Solutions (1)How chromatids become independent chromosomes and move toward tw poles during anaphase of mitosis (2)Mechanisms of cell eycle regulation
7. Knowledge recalling and Assignment (15min) Total 90 min Assignment/ Thinking Questions Thinking Questions 1. What is chromatin and what is chromosome? 2. What is the relationship between chromatin behavior and cell cycling? 3. How to understand DNA packaging and their evolution mechanism Postscript 1. When explain DNA and their packaging pattern, using some economic thought. 2. Make student get easy to understand cell cycling and chromatin behaviors. Memo Chapter 7 ：Cell cycle and its regulation Teacher's Name: Ying-Yu Cui Teaching Objectives; Teaching Requirements Objectives: (1) grasp the concept of cell cycle and its main phases; (2) grasp of the similarity and difference between mitosis and meiosis (3) learn of the regulatory mechanism of cell division and its relation with some diseases’ occurrence Requirements: Computer, Projector, laser pointer, microphone Teaching Content (1) overview of cell cycle (2) regulation of cell cycle (3) cell division: mitosis vs meiosis (4) cell cycle and medicine (5) cell division and diseases Teaching Focus; Difficult Problems and Their Solutions Foci: (1) concept of cell cycle, checkpoints and the characteristics of each phase (2) Cyclins, CDK, CDKI, PMF and their roles in cell cycle regulation Difficult points: (1)How chromatids become independent chromosomes and move toward two poles during anaphase of mitosis (2) Mechanisms of cell cycle regulation
Time Allotment (1)Compare the similarity and difference between mitosis and meiosis Assignment/ (2)How to understand the relationship of cell cycle control and carcinogenesis Thinking (3)Analyze the significance of cell cycle regulation in R&D of anti-cancer drug Questions Postscript Memo Chapter 8:Cell differentiation Teacher's Name:Zhi-Hua shao Teaching Objectives; of cells of mammalian body (germ cells,somatic cells and stem Teaching cells),concept and sorts of stem cells,stem-cell engineering and Requirements regenerative medicine. Grasp these basic concepts,and know the essence and mechanism of cell diffe tion and its regulation. of thei application in clinical medicine. Requirements:Computer,Projector,laser pointer,microphone. 1.Introduction of the biology of cell differentiation,cells with potency of differentiation and the properties of stem cells; Teaching Embryonic stem cells,adult ste and embryonic germ cells Content Epigenetic regulation of cell differentiation; 4. The major cell differentiation systems
Time Allotment Assignment/ Thinking Questions (1) Compare the similarity and difference between mitosis and meiosis (2) How to understand the relationship of cell cycle control and carcinogenesis (3) Analyze the significance of cell cycle regulation in R&D of anti-cancer drugs Postscript Memo Chapter 8：Cell differentiation Teacher's Name: Zhi-Hua Shao Teaching Objectives; Teaching Requirements 1. Introduce the basic concepts of stem cell, cell differentiation, dedifferentiation, and trans-differentiation; three basic categories of cells of mammalian body (germ cells, somatic cells and stem cells), concept and sorts of stem cells, stem-cell engineering and regenerative medicine. 2. Grasp these basic concepts, and know the essence and mechanism of cell differentiation and its regulation. Learn of their application in clinical medicine. Requirements: Computer, Projector, laser pointer, microphone. Teaching Content 1. Introduction of the biology of cell differentiation , cells with potency of differentiation and the properties of stem cells; 2. Embryonic stem cells, adult stem cells and embryonic germ cells; 3. Epigenetic regulation of cell differentiation; 4. The major cell differentiation systems
Teaching 1.The mechanism of cell differentiation should be clarified through some case; 2. Epigenetic regulation of cell differentiation is a complex case Problems and should be explained in detail. Their Solutions 8. Introduction (10min) stem cells (20 min) Time 10.Epigenetic regulation of cell differentiation (40 min) Allotment 11.The major cell differentiation systems. (20 min) Total 90min 1.How do you think genes can be responsible for cellular Assignment differer ces? Thinking How do you think cell differentiation affects an organism? Questions Try to orientate your students towards the science subjects by Postscript oduce some milestone events,for instant,the establishment of ips cells. Memo Chapter9:Se ence and death Teacher's Name:Shane Gao Intr oduce cell senescence,cell apoptosis and cell death Teaching ckground; Objectives, Make students clear about the above concepts: Teaching 5.Guide the students to understand the principle of cell senescence, Requirements cell apoptosis and cell death,make sure they can understand them from many aspects such as celluar level,genetic level,etc Requirements:Computer.Projector,laser pointer,microphone 5. Cell senescence background introduction and principle Teaching mechanism: Content 6.Cell Apoptosis backeround introduction and principle mechanism Comp ring ence and cell apoptosis 8 Link between cell senescence,cell apoptosis and cell death
Teaching Focus; Difficult Problems and Their Solutions 1. The mechanism of cell differentiation should be clarified through some case; 2. Epigenetic regulation of cell differentiation is a complex case should be explained in detail. Time Allotment 8. Introduction (10min) 9. Stem cells (20 min) 10. Epigenetic regulation of cell differentiation (40 min) 11. The major cell differentiation systems. (20 min) Total 90min Assignment/ Thinking Questions 1. How do you think genes can be responsible for cellular differences? 2. How do you think cell differentiation affects an organism? Postscript Try to orientate your students towards the science subjects by introduce some milestone events, for instant, the establishment of ips cells. Memo Chapter9: Senescence and death Teacher's Name: Shane Gao Teaching Objectives; Teaching Requirements 4. Introduce cell senescence, cell apoptosis and cell death background; Make students clear about the above concepts; 5. Guide the students to understand the principle of cell senescence, cell apoptosis and cell death, make sure they can understand them from many aspects such as cellular level, genetic level, etc. Requirements: Computer, Projector, laser pointer, microphone. Teaching Content 5. Cell senescence background introduction and principle mechanism; 6. Cell Apoptosis background introduction and principle mechanism; 7. Comparing cell senescence and cell apoptosis; 8. Link between cell senescence, cell apoptosis and cell death
Teaching 4.The relationship between cell senescence and body senescence is a difficult problem to understand; 5 and cell death should be clarified through many Problems and phenomenon; Their Solutions Cell apoptosis process is a complex and multiple one should be exolained in detail 1 Introduction and objectives (10min) 23 Principles (20min) Time Comparison of cell senescence and apoptosis (20 min) Allotment Cell senescence mechanism (20min) 5.Cell apoptosis mechanism (30 min) 6.Link between cell senescence and cell apoptosis (30 min 7.Link between body senescence and cell senescenece (30 min) Knowledge recalling Assignment (20min) Total 180min 4.What is the principle of cell senescence and cell apoptosis? Assignment 5.What is the relationship between cell senescence and body Thinking senescence Questions 6.How to distinct cell senescence and cell apoptosis? 7.Why cells get senescence or apoptosis? 3.When explain cell apoptosis and cell senescence,teacher can Postscript combine from cancer 4 Make student get easy to understand cell events by provide some milestone example. Memo Chapter 10:Cell communication Teacher's Name:Yi Sun Objectives: Teaching (1)grasp the concept of cell recognition and cell communication Objectives: (2)grasp of the cell signaling molecules and their receptors, Teaching (3)learn of the different signaling pathways that different receptors mediate; Requirements (4)learn of primary features of signal transduction and the network integration information of protein kinase (5)leam of cell signaling and disease Requirements:Computer,Projector,laser pointer,microphone
Teaching Focus; Difficult Problems and Their Solutions 4. The relationship between cell senescence and body senescence is a difficult problem to understand; 5. Cell apoptosis and cell death should be clarified through many phenomenon; 6. Cell apoptosis process is a complex and multiple one should be explained in detail. Time Allotment 1. Introduction and objectives (10min) 2. Principles (20min) 3. Comparison of cell senescence and apoptosis (20 min) 4. Cell senescence mechanism ( 20min) 5. Cell apoptosis mechanism (30 min) 6. Link between cell senescence and cell apoptosis (30 min) 7. Link between body senescence and cell senescenece (30 min) Knowledge recalling Assignment (20min) Total 180min Assignment/ Thinking Questions 4. What is the principle of cell senescence and cell apoptosis ? 5. What is the relationship between cell senescence and body senescence? 6. How to distinct cell senescence and cell apoptosis ? 7. Why cells get senescence or apoptosis? Postscript 3. When explain cell apoptosis and cell senescence, teacher can combine information from cancer. 4. Make student get easy to understand cell events by provide some milestone example. Memo Chapter 10：Cell communication Teacher's Name: Yi Sun Teaching Objectives; Teaching Requirements Objectives: (1) grasp the concept of cell recognition and cell communication; (2) grasp of the cell signaling molecules and their receptors; (3) learn of the different signaling pathways that different receptors mediate; (4) learn of primary features of signal transduction and the network integration information of protein kinase; (5) learn of cell signaling and disease. Requirements: Computer, Projector, laser pointer, microphone