第十五章羧酸衍生物 1.如何合成下列化合物 CICOCgHo CICOCH,C6H5 4)HSC2OCOC2H5 (5) HN一 (6)CH3NHCNHC,H 2.写出下列化合物的结构式。 (1)丁酸丙酯 (2)N-甲基苯甲酰胺 (3)N,N-二乙基乙酰胺 (4)乙酸苯酯 (5)苯甲酸卞酯 (6)对苯二甲酰氯 3.写出下列反应的产物。 (1)CH3COCH3+H,1%0_H' CH3C— -CH2CH2 CH2CH(CH3)2 H,0 HCL. CH 4.写出下列反应的产物
第十五章 羧酸衍生物 1． 如何合成下列化合物。 (1) H2C CHCH(OC2H5)2 (2) ClCOC4H9 -n O (3) ClCOCH2C6H5 O (4) H5C2OCOC2H5 O (5) O C HN C HN C O O (6) CH3NHCNHC2H5 O 2. 写出下列化合物的结构式。 (1) 丁酸丙酯 (2) N-甲基苯甲酰胺 (3) N,N-二乙基乙酰胺 (4) 乙酸苯酯 (5) 苯甲酸卞酯 (6) 对苯二甲酰氯 3．写出下列反应的产物。 (1) CH3COCH3 O + H2 18O H + (2) CH3COC(CH3 )3 O + H2 18O H + (3) + H2O H + CH3C O O C CH3 CH2CH2CH2CH(CH3)2 C2H5 (4) C COOC(CH3)3 CH3 O H3CO -OH(1mol), H2O (5) C COOC(CH3)3 CH3 O H3CO HCl, CH2Cl2 (6) C CH2 H3CCO C6H5 O -OH, H2O 4. 写出下列反应的产物
(1)CH3CCI+ CH3 OH (CH3hCCH, CH, COCI CH:OH CH3COCCH CH-CH_CH( CH3h CHIOH 旋光 5.写出下列反应的产物 (2)HO* NC(CH2) CHo (1)CAHs MgBr(Imol) CsHas-n (2)H3O LiCu(CHah cocl (I)CHSM (1)CH3 Mgl HCN(CH3)(2)H3O* (LiAIH (2)H2O C2H5 6.写出下列反应的产物、中间产物或试剂
(1) CH3CCl O + CH3 18OH C5H5N (2) NH2 CO2H + ClCCl O (3) (CH3 )2CCH2CH2COCH3 NH2 O CH3OH (4) CH3COCCH2CH2CH2CH(CH3 )2 O CH3 CH3 H+ CH3OH 旋 光 5. 写出下列反应的产物。 (1) O O C5H11 -n (1) CH3MgBr (2) H3O + (2) NC(CH2 )3CHO (1) C6H5MgBr(1mol) (2) H3O + (3) O2N COCl LiCu(CH3 )2 (4) (2) H3O + F3C C N (1) CH3MgI (5) (2) H3O + (1) CH3MgI HCN(CH3 )2 O (6) NH O C2H5 (1) LiAlH4 (2) H2O 6. 写出下列反应的产物、中间产物或试剂。 (1) O C O OEt OH -
()CH3 Mgl, Et,O CH,_CH, COCH-CH3 (2)H3O RHNH2CHzCOC 戊烷→? HOC (1)LiAlH4 (1)2CHM1 (2)H3O 7.如何实现下列转变? (1)(CH3) CHCH2 COOH (CH3hCHCH CH NHC6H5 C6HSCH C6HsCH2COOH (3) C6H5CH3 CH3CH,CH, COOH CH3CH, CCH,CH2 CH (5)C6H3COOH (C6H5)3 CNHCOCH3 COCH2 CH2 CH2 CH3 HOOCCH-CH,COOF CH3OCCH2 CH COC6Hs
(2) (2) H3O + (1) CH3MgI, Et2O CH3CCH2CH2COCH2CH3 O O (3) RHNH2CH2COC O NO2 戊 烷 ？ H2O HOC O NO2 +? (4) + ? NHCCH3 O (5) (1) LiAlH4 (2)H2O O O (6) (1) 2CH3MgI (2)H3O + O O (7) H3C CH3 C O NH2 H3C CH3 H2N 7. 如何实现下列转变？ (1) (CH3 )2CHCH2COOH (CH3 )2CHCH2CH2NHC6H5 (2) C6H5CH3 C6H5CH2COOH (3) C6H5CH3 C6H5NH2 (4) CH3CH2CH2COOH CH3CH2CH2CCH2CH2CH3 CH3 OH (5) C6H5COOH (C6H5 )3CNHCOCH3 (6) CH3 Br CH3 COCH2CH2CH2CH3 (7) HOOCCH2CH2COOH CH3OCCH2CH2COC6H5 O O