上游充通大学 SHANGHAI JIAO TONG UNIVERSITY 教材： 编者： ●JEREMY M.BERG -Ph.D.in chemistry from Harvard Biochemistry -Professor of Johns Hopkins University,School of Medicine -Director of the Department of Biophysics and Biophysical Chemistry ●JOHN L.TYMOCZKO -Towsley Professor of Biology at Jeremy M.Berg Carleton College John L.Tymoczko Lubert Stryer (第六版) ●LUBERT STRYER -Winzer Professor of Cell Biology, School of Medicine And Professor of Neurobiology at Stanford University
教材： 编者： • JEREMY M. BERG -Ph.D. in chemistry from Harvard -Professor of Johns Hopkins University, School of Medicine -Director of the Department of Biophysics and Biophysical Chemistry • JOHN L. TYMOCZKO -Towsley Professor of Biology at Carleton College • LUBERT STRYER -Winzer Professor of Cell Biology, School of Medicine And Professor of Neurobiology at Stanford University （第六版）
上降充通大学 SHANGHAI JIAO TONG UNIVERSITY Chapter 1: Biochemistry:An Evolving Science Berg·Tymoczko·Stryer Biochemistry Sixth Edition
Berg • Tymoczko • Stryer Biochemistry Sixth Edition Chapter 1: Biochemistry: An Evolving Science
上游充通大学 SHANGHAI JIAO TONG UNIVERSITY Biochemistry Biochemistry:the study of the chemistry of life processes. Disease and the genome the malfunctioning q31.2 gene for cystic fibrosis. chromosome Human chromosome 7
Disease and the genome the malfunctioning gene for cystic fibrosis. chromosome Human chromosome 7 Biochemistry: the study of the chemistry of life processes. Biochemistry
上游充通大￥ SHANGHAI JIAO TONG UNIVERSITY 1828,the discovery that biological molecules such as urea (could be synthesized from nonliving components, scientists have explored the chemistry of life. Many of the most fundamental mysteries of how living things function have now been solved.However,much remains to be investigated.(很多未知) the application of our tremendous knowledge of biochemistry to problems in medicine,agriculture, environmental sciences...(已知与应用的联系) One of the most startling discoveries of the past century:the great unity of all living things at the biochemical level所有生物在生化水平上的统一性
1828, the discovery that biological molecules such as urea （尿素）could be synthesized from nonliving components, scientists have explored the chemistry of life. Many of the most fundamental mysteries of how living things function have now been solved. However, much remains to be investigated. （很多未知） the application of our tremendous knowledge of biochemistry to problems in medicine, agriculture, environmental sciences…….（已知与应用的联系） One of the most startling discoveries of the past century: the great unity of all living things at the biochemical level 所有生物在生化水平上的统一性
上降充通大学 SHANGHAI JIAO TONG UNIVERSITY OUTLINES 1.Biochemical Unity Underlies Biological Diversity 2.DNA Illustrates the Interplay between Form and Function 3.Concepts from Chemistry Explain the Properties of Biological Molecules 4.The Genomic Revolution Is Transforming Biochemistry and Medicine
1. Biochemical Unity Underlies Biological Diversity 2. DNA Illustrates the Interplay between Form and Function 3. Concepts from Chemistry Explain the Properties of Biological Molecules 4.The Genomic Revolution Is Transforming Biochemistry and Medicine OUTLINES
上游充通大￥ SHANGHAI JIAO TONG UNIVERSITY OUTLINES 1.Biochemical Unity Underlies Biological Diversity 2.DNA Illustrates the Interplay between Form and Function 3.Concepts from Chemistry Explain the Properties of Biological Molecules 4.The Genomic Revolution Is Transforming Biochemistry and Medicine
1. Biochemical Unity Underlies Biological Diversity 2. DNA Illustrates the Interplay between Form and Function 3. Concepts from Chemistry Explain the Properties of Biological Molecules 4.The Genomic Revolution Is Transforming Biochemistry and Medicine OUTLINES
上游充通大学 Biological diversity and similarity SHANGHAI JIAO TONG UNIVERSITY Geological and biochemical findings Oxygen atmosphere sunesou! ↓ ↓ ↓ forming ↓ ↓ 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 0.5 0.0 Billions of years Key metabolic processes: glucose and oxygen carbon dioxide and water E.Coli human beings Sulfolobus acidicaldarius Arabidopsis thaliana Homo sapiens
Biological diversity and similarity Key metabolic processes： glucose and oxygen carbon dioxide and water E. Coli & human beings Geological and biochemical findings
上游充通大学 SHANGHAI JIAO TONG UNIVERSITY BACTERIA EUKARYA ARCHAEA Carl Woese's discovery in1977. Figure 1.3 The tree of life. Evolutionary paths from a common ancestor to modern organisms can be deduced on the basis of biochemical information
Figure 1.3 The tree of life. Carl Woese‘s discovery in 1977. Evolutionary paths from a common ancestor to modern organisms can be deduced on the basis of biochemical information
上游充通大粤 SHANGHAI JIAO TONG UNIVERSITY Comparing and contrasting details of particular biochemical pathways in different organisms how biological challenges are solved at the biochemical level. In most cases,these challenges are addressed by the adaptation of existing macromolecules 物大分子适应性to new roles rather than by the evolution of entirely new ones. Structure Function
Comparing and contrasting details of particular biochemical pathways in different organisms • how biological challenges are solved at the biochemical level. • In most cases, these challenges are addressed by the adaptation of existing macromolecules 生 物大分子适应性 to new roles rather than by the evolution of entirely new ones. Structure & Function
上游充通大￥ SHANGHAI JIAO TONG UNIVERSITY OUTLINES 1.Biochemical Unity Underlies Biological Diversity 2.DNA Illustrates the Interplay between Form and Function 3.Concepts from Chemistry Explain the Properties of Biological Molecules 4.The Genomic Revolution Is Transforming Biochemistry and Medicine
1. Biochemical Unity Underlies Biological Diversity 2. DNA Illustrates the Interplay between Form and Function 3. Concepts from Chemistry Explain the Properties of Biological Molecules 4.The Genomic Revolution Is Transforming Biochemistry and Medicine OUTLINES