Hypersensitivity(超敏反应) Qingqing Wang Institute of immunology Zhejiang University School of Medicine wqq@zju.edu.cn
Hypersensitivity (超敏反应) Qingqing Wang Institute of Immunology Zhejiang University School Of Medicine wqq@zju.edu.cn
a Hypersensitivity Some immune responses can give rise to an excessive or inappropriate reaction resulting in significant tissue damage or even death a The classification: type INIV
Hypersensitivity Some immune responses can give rise to an excessive or inappropriate reaction, resulting in significant tissue damage or even death. The classification: type I~IV
I型--速发型(IgE) ∏型---细胞毒型 I型--免疫复和物型(IgG) ⅣV型--迟发型(TDm) Robin Coombs Philip george houthem gell 1921-2006 1914-2001
Robin Coombs 1921 - 2006 I型 ---- 速发型（IgE） II型 ---- 细胞毒型（IgG，IgM） III型 ---- 免疫复和物型（IgG） IV型 ---- 迟发型（TDTH） ---------------------------------------------- Philip George Houthem Gell 1914 - 2001
ype of Pathologic immune Mechanisms of tissue hypersensitivity mechanisms injury and disease Immediate TH2 cells, IgE antibody, mast cells, eosinophils Mast cell-derived hypersensitivity mediators (vasoactive amine Types of (Type I) Mast cell lipid mediators, cytokines) Cytokine-mediated hypersensitivity nflammation(eosinophils Allergen neutrophils) diseases Antibody- gM,lgG antibodies against cell surface or Complement-and Fc receptor- mediated extracellular matrix antigens In the four major diseases Inflammatory cell activation of leukocytes (Type II) F (neutrophils, macrophages) types of Opsonization and phagocytosis of cells persensitivity Abnormalities in cellula Antibody function, e.g., homone receptor signaling reactions different Immune Immune complexes of circulating antigens Complement and Fc receptor immune effector complex and IgM or IgG antibodies deposited in mediated recruitment and mediated activation of leukocytes mechanisms cause diseases Neutrophils Blood tissue injury and disease Antigen-antibody T cell- 1.CD4+T cells(delayed-type hypersensitivity) 1. Macrophage activation mediated 2. CDB+CTLs (T cell-mediated cytolysis) cytokine-mediated diseases inflammation (Type Iv) Macrophage 2. Direct target cell lysis OElsevierAbbas&Lichtman:BasicImmunclogy,updated2e-www.studentconsult.com
Types of hypersensitivity diseases. In the four major types of hypersensitivity reactions, different immune effector mechanisms cause tissue injury and disease
Type I hypersensitivity (immediate hypersensitivity)
Type I hypersensitivity (immediate hypersensitivity)
Richet和 Porter提出了过敏反应的概念, 二人因此获1913年诺贝尔奖。 初次注射 海葵毒素 导致狗死亡 再次注射 海葵毒素 无明显反应 anaphylaxis
初次注射 海葵毒素 无明显反应 再次注射 海葵毒素 导致狗死亡 Richet和Porteir提出了过敏反应的概念， 二人因此获1913年诺贝尔奖。 anaphylaxis
Type I hypersensitivity Carl Prausnitz-Giles 1876-1963
Carl Prausnitz-Giles 1876-1963 Type I hypersensitivity
1921 Prausnitz-Kustner test ---reagin 1
Prausnitz-Kustner test --- “reagin” 1921
1:10 1:100 1:1000 1:10000
1966 Reagin=lge Kimishige Ishizaka (1925-)and Teruka ishizaka
Kimishige Ishizaka（1925-）and Teruka Ishizaka Reagin = IgE 1966