Childhood hematopoiesis,hematological features and nutritional anemia Yongmin Tang Dept.Hematology-oncology Children's Hospital Zhejiang University School of medicine THE CHILDREN'S HOSPITAL ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE 浙江大学医学院附属儿童医院
Childhood hematopoiesis, hematological features and nutritional anemia Yongmin Tang Dept. Hematology-oncology Children’s Hospital Zhejiang University School of medicine
Hematopoietic Stem Cells (HSC),CD34 is the marker of HSCs.All the daughter blood cells are derived from the HSCs. 5um THE CHILDREN'S HOSPITAL ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE 浙江大学医学院附属儿童医院
Hematopoietic Stem Cells (HSC), CD34 is the marker of HSCs. All the daughter blood cells are derived from the HSCs. 5 um
Early development of the fertilized egg. Inner Cell M In Vitro Fertilization Totipotent I Blastocyst Fetus Human 1-_Cells_ THE CHILDREN'S HOSPITAL ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE 浙江大学医学院附属儿童医院
Early development of the fertilized egg
Development of hematopoietic stem cells Totipotent Cells Blood Stem Cells Other committed Stem Cells Specialized Red Blood White Bloodl Cells Cells Platelets
Development of hematopoietic stem cells
The features of the hematopoiesis in children HEMATOPOIESIS DURING FETAL DEVELOPMENT 1.Mesoblastic hematopoiesis:3rd-6th wks 2.Hepatic hematpoiesis:2nd-6th months 3.Medullary hematopoiesis:4th-5th months -yalk sac -liver 一BM 0 、9619心959心的9中的 (Wks) THE CHILDREN'S HOSPITAL ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE 浙江大学医学院附属儿童医院
The features of the hematopoiesis in children 0 2 4 6 8 10 12 1 3 5 7 9 1 1 1 3 15 1 7 1 9 21 23 2 5 2 7 2 9 3 1 3 3 35 3 7 3 9 yalk sac liver BM (Wks） HEMATOPOIESIS DURING FETAL DEVELOPMENT 1. Mesoblastic hematopoiesis: 3rd – 6th wks 2. Hepatic hematpoiesis: 2nd - 6th months 3. Medullary hematopoiesis: 4th-5th months
Hematopoiesis during fetal development Islet of Yolk Sac In liver In BM Mesoblastic Hepatic Madullary liver BM HSC Migration of HSCs THE CHILDREN'S HOSPITAL ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE 浙江大学医学院附属儿童医院
Hematopoiesis during fetal development Islet of Yolk Sac In liver In BM Migration of HSCs liver BM HSC Mesoblastic Hepatic Madullary
HEMAYOPOIESIS AFTER BIRTH 1.Medullary hematopoiesis: “red marrow” “yellow marrow” When needed:Yellow marrow >red marrow >hematopoiesis compensation 2.Extramedullary hematopoiesis: hepatosplenomegaly with circulating nucleated erythrocytes in the blood stream THE CHILDREN'S HOSPITAL ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE 浙江大学医学院附属儿童医院
hepatosplenomegaly with circulating nucleated erythrocytes in the blood stream HEMAYOPOIESIS AFTER BIRTH 1. Medullary hematopoiesis: “red marrow” “yellow marrow” When needed: Yellow marrow Æred marrow Æhematopoiesis compensation 2. Extramedullary hematopoiesis:
Blood pictures in children (1) A.RBC EPO CRBC 000 Fetal stage: RBC 5~7x 1012/L Hb150~220g/L THE CHILDREN'S HOSPITAL ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE 浙江大学医学院附属儿童医院
Blood pictures in children (1) renal vascular plexus epithelium A. RBC Æ EPO Æ RBC Fetal stage: RBC 5 ~ 7 x 1012/L Hb 150 ~ 220g/L
Blood pictures in children (2) Physiological hemolysis: circulating nucleated RBC with elevated reticulocytes (stopping lysing within 1wk) Physiological anemia: infant 2-3 months RBC 3 x1012/L Hb 110 g/L (self-limited,recover within 6 months) THE CHILDKEN S HOSPITAL ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE 浙江大学医学院附属儿童医院
Blood pictures in children (2) Physiological hemolysis: circulating nucleated RBC with elevated reticulocytes (stopping lysing within 1wk) Physiological anemia: infant 2-3 months RBC 3 x1012/L Hb 110 g/L (self-limited, recover within 6 months)
Blood pictures in children (3) Reticulocytes: 0-3d 4-7d 4-6wk after 5mon 4-6% 0.5-1.5% 2-8% 0.5-1.5% THE CHILDREN'S HOSPITAL ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE 浙江大学医学院附属儿童医院
0 - 3d 4-7d 4-6wk after 5mon 4 - 6% 0.5-1.5% 2-8% 0.5-1.5% Reticulocytes ： Blood pictures in children (3)